ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants.

Aging
Chia-Ling KuoDavid Melzer

Abstract

The Apolipoprotein E (APOE) e4 allele is associated with reduced longevity and increased Coronary Artery Disease (CAD) and Alzheimer's disease, with e4e4 having markedly larger effect sizes than e3e4. The e2 longevity promoting variant is less studied. We conducted a phenome-wide association study of ApoE e2e3 and e2e2 with aging phenotypes, to assess their potential as targets for anti-aging interventions. Data were from 379,000 UK Biobank participants, aged 40 to 70 years. e2e3 (n=46,535) had mostly lower lipid-related biomarker levels including reduced total and LDL-cholesterol, and lower risks of CAD (Odds Ratio=0.87, 95% CI: 0.83 to 0.90, p=4.92×10-14) and hypertension (OR=0.94, 95% CI: 0.92 to 0.97, p=7.28×10-7) versus e3e3. However, lipid changes in e2e2 (n=2,398) were more extreme, including a marked increase in triglyceride levels (0.41 Standard Deviations, 95% CI: 0.37 to 0.45, p=5.42×10-92), with no associated changes in CAD risks. There were no associations with biomarkers of kidney function. The effects of both e2e2 and e2e3 were minimal on falls, muscle mass, grip strength or frailty. In conclusion, e2e3 has protective effects on some health outcomes, but the effects of e2e2 are not similar, complicating the poten...Continue Reading

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Citations

May 27, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chia-Ling KuoDavid Melzer
Oct 27, 2020·European Archives of Psychiatry and Clinical Neuroscience·Timotius Ivan HariyantoAndree Kurniawan
Jan 27, 2021·The American Journal of the Medical Sciences·Timotius Ivan HariyantoAndree Kurniawan
Dec 8, 2020·Archives of Gerontology and Geriatrics·Timotius Ivan HariyantoAndree Kurniawan
Jul 2, 2021·Alzheimer's Research & Therapy·May A BeydounAlan B Zonderman
Aug 8, 2021·International Journal of Molecular Sciences·Yang WuPing Song
Aug 10, 2021·World Journal of Virology·Stanislav Vasilev KotsevTsvetelina Velikova

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Methods Mentioned

BETA
genotyping

Software Mentioned

KING
R

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