Abstract
Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder with complex etiology involving both genetic and environmental factors. Apolipoprotein E (ApoE) rs405509 (-219 T/G), a promoter SNP, controls the expression of APOE gene, and plays a modifier effect of APOE ε4 on the susceptibility of Alzheimer's disease. In this study, we investigate the association between APOE rs405509 polymorphism and the susceptibility of PD in a Chinese population. A total of 1020 subjects were collected including 510 sporadic PD patients (mean age: 63.11 ± 9.28 years) and 510 healthy control subjects (mean age: 62.97 ± 9.09 years). APOE rs405509 polymorphism was genotyped using a TaqMan genotyping method. The Hardy-Weinberg Equilibrium (HWE) was calculated for the control group by Chi-square (χ2) test. The strength of this association between the APOE rs405509 polymorphism and PD risk was evaluated with crude odds ratios (ORs) and 95 % confidence intervals (CIs) using a logistic regression analysis. The T allele frequency was 0.84 and 0.70 in the PD and control groups, respectively. T allele carriers of rs405509 were associated with an increased overall risk of PD and in male subjects in the allele, recessive, and a...Continue Reading
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