PMID: 8457389Jan 1, 1993Paper

Apolipoprotein (a) concentrations and susceptibility to coronary artery disease in patients with peripheral vascular disease

British Heart Journal
P GrovesR Hall

Abstract

To investigate the relation between apolipoprotein(a) concentrations and angiographically defined coronary artery disease in patients with atheromatous peripheral vascular disease. 40 consecutive patients were recruited at the time of admission for peripheral vascular surgery. All underwent clinical assessment and coronary arteriography. Apolipoprotein(a) concentrations were measured by an immunoradiometric assay. Tertiary referral centre. Patients requiring surgical intervention for large vessel peripheral vascular disease. Presence or absence and severity and distribution of angiographically defined coronary artery disease. Measurement of circulating contractions of apolipoprotein(a) and other lipid indices. Coronary artery disease was absent in 11 patients (group 1), mild to moderate in 12 (group 2), and severe in 17 (group 3). The distribution of peripheral vascular disease and of standard lipid indices was similar in these three groups of patients. There was a significant difference in apolipoprotein(a) concentrations between the three groups, with concentrations progressively increasing with the severity of coronary artery disease (mean (95% confidence interval): group 1, 112 U/1 (52 to 242); group 2, 214 U/1 (129 to 355)...Continue Reading

References

May 27, 1978·British Medical Journal·W G HughsonA Garrod
Feb 6, 1992·The New England Journal of Medicine·M H CriquiD Browner
Jul 1, 1991·Journal of the American College of Cardiology·B J GershD J Ballard
Mar 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J LoscalzoA M Scanu
Feb 18, 1989·BMJ : British Medical Journal·F G Fowkes
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P C HarpelT S Parker
Nov 17, 1989·Science·G Utermann
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Nov 9, 1989·The New England Journal of Medicine·K E RabyA P Selwyn
Nov 1, 1985·Atherosclerosis·A GurakarH B Brewer
Sep 1, 1986·Stroke; a Journal of Cerebral Circulation·G ZenkerG Jürgens
Aug 1, 1987·The Journal of Clinical Investigation·G UtermannC Seitz
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D L EatonA M Scanu
Jan 1, 1986·Human Heredity·O Mayo, D J Street
Feb 1, 1987·Journal of the American College of Cardiology·J LeppoB S Cutler
Feb 14, 1985·The New England Journal of Medicine·C A BoucherG M Pohost
Mar 19, 1966·Lancet·D D ReidG Rose
May 30, 1981·Lancet·E B Smith, E M Staples
Jan 1, 1982·Annals of Nutrition & Metabolism·E MarthG M Kostner
May 9, 1980·JAMA : the Journal of the American Medical Association·P SorlieW B Kannel
Jun 1, 1980·Circulation·W B KannelD L McGee
Jan 1, 1981·Atherosclerosis·G M KostnerG B Qunici

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.