Apolipoprotein A-I, A-II, and VLDL-B-100 metabolism in men: comparison of a low-fat diet and a high-monounsaturated fatty acid diet.

Journal of Lipid Research
Sophie DesrochesBenoît Lamarche

Abstract

The impact of a low-fat diet and a high-MUFA diet on apolipoprotein A-I (apoA-I), apoA-II, and VLDL-apoB-100 metabolism in conditions of unrestricted (ad libitum) energy intake was compared in 65 men randomly assigned to one of two predefined experimental diets. A subsample of 18 men participated in the kinetic study. Before and after the 6-7 week dietary intervention, kinetic subjects received a primed-constant infusion of [5,5,5-2H3]L-leucine for 12 h under feeding conditions. ApoA-I production rate (PR; -31.5%; P <0.001) and fractional catabolic rate (FCR; -24.3%; P <0.05) were significantly decreased after the low-fat diet. These changes in apoA-I PR and FCR with the low-fat diet were also significantly different from those observed with the high-MUFA diet (P <0.01 and P <0.05, respectively). ApoA-II FCR was significantly increased in the high-MUFA group only. No significant within- or between-diet difference was found in VLDL-apoB-100 PR or FCR. These results emphasize the differential impact of the low-fat diet and high-MUFA diet on HDL metabolism.

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Citations

Feb 15, 2007·European Journal of Clinical Nutrition·S DesrochesB Lamarche
Sep 22, 2009·The American Journal of Cardiology·Hope R Ferdowsian, Neal D Barnard
May 22, 2009·Clinical Science·Theodore W K NgGerald F Watts
Jan 22, 2015·Nutrition Journal·Jean-Philippe Drouin-ChartierBenoît Lamarche
Jan 1, 2015·Current Opinion in Lipidology·Benoît Lamarche, Patrick Couture
Feb 24, 2006·Journal of Lipid Research·Jean-François MaugerBenoît Lamarche
Feb 18, 2018·European Journal of Clinical Nutrition·Theocharis KoufakisKalliopi Kotsa
Jun 21, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Martin AdielsJan Borén
Jul 12, 2017·Journal of Nutrition and Metabolism·Lotte SmoldersRonald P Mensink
May 31, 2013·The American Journal of Clinical Nutrition·André J TremblayPatrick Couture
Mar 25, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Abderrahim OussalahJean-Louis Guéant

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