Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease

The New England Journal of Medicine
J J MaciejkoS J Mao

Abstract

This study was designed to determine whether the plasma level of apolipoprotein A-I is a better discriminator of angiographically documented coronary-artery disease than the level of high-density-lipoprotein (HDL) cholesterol in male subjects. The level of plasma apolipoprotein A-I in 83 patients with coronary-artery disease was 96.7 +/- 4.2 mg per deciliter (mean +/- S.E.M.), which was significantly lower (P less than 0.0001) than the level in 25 patients without coronary-artery disease (146.9 +/- 2.1 mg per deciliter). The levels of HDL cholesterol were also lower (P less than 0.0001) in patients with coronary-artery disease (31.9 +/- 1.5 mg per deciliter) than in those without it (45.9 +/- 2.3 mg per deciliter). A stepwise discriminant analysis, however, indicated the superiority of apolipoprotein A-I over HDL cholesterol in detecting coronary-artery disease. Furthermore, a linear discriminant analysis suggested that although HDL cholesterol by itself was a discriminator of coronary-artery disease, it did not provide a substantial increase in discriminatory value over that provided by apolipoprotein A-I; in contrast, apolipoprotein A-I levels added discriminatory value to the information obtained by measuring HDL cholesterol...Continue Reading

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References

Apr 1, 1976·Physiological Reviews·R L JacksonA M Gotto
Aug 1, 1977·Metabolism: Clinical and Experimental·J D BrunzellD J Sherrard
Aug 1, 1977·Diabetologia·M F Lopes-VirellaJ A Colwell
Apr 1, 1978·Metabolism: Clinical and Experimental·J J AlbersW R Hazzard
Jan 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·E J SchaeferH B Brewer
Apr 1, 1982·Atherosclerosis·G De BackerJ P Deslypere
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A SnidermanP O Kwiterovich
Jan 1, 1980·Annual Review of Medicine·G J Miller
Jul 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G FagerG Bondjers

❮ Previous
Next ❯

Citations

Jan 1, 1992·Journal of Clinical Laboratory Analysis·B HarakeR J Thibert
Apr 1, 1988·European Journal of Pediatrics·U QuerfeldK Schärer
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·E VollmerW Böcker
Jan 4, 1991·Klinische Wochenschrift·H PollakD Trubert-Exinger
Mar 1, 1986·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·K Fotherby
May 1, 1986·Journal of General Internal Medicine·W L Peters, A H Goroll
Jan 1, 2001·Indian Journal of Clinical Biochemistry : IJCB·R Sharma, V S Singh
Aug 12, 2006·Current Atherosclerosis Reports·Natalie Khuseyinova, Wolfgang Koenig
Jun 1, 1985·The American Journal of Cardiology·S B SchmidtA M Ross
Feb 27, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·N RifaiR G Holly
Dec 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·M BojanovskiH B Brewer
Nov 1, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·P S Bachorik, P O Kwiterovich
Feb 22, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·X L WangD E Wilcken
Mar 15, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·C J GlueckJ Speirs
Jun 15, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·A GaverL Wong
Dec 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·S S Levinson, S G Wagner
Jun 30, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·G A HobbsS S Levinson
Nov 1, 1988·Atherosclerosis·R Kauppinen-Mäkelin, E A Nikkilä
Jan 1, 1988·Atherosclerosis·S E Olpin, C P Price
Feb 1, 1992·Atherosclerosis·J SteinmetzG Siest
Apr 1, 1990·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J P DeslypereM Thiery
Jan 1, 1988·Pharmacology & Therapeutics·C R Sirtori, G Franceschini
Dec 8, 1993·Gene·V N TrieuD D Black
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J H IpJ H Chesebro
Sep 1, 1992·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·M Sanchez BayleJ Baeza
Apr 17, 2004·Clinical Biochemistry·Christina PiperiAnastasios Kalofoutis

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