Apolipoprotein A-I induces translocation of protein kinase C[alpha] to a cytosolic lipid-protein particle in astrocytes.

Journal of Lipid Research
Jin-ichi ItoShinji Yokoyama

Abstract

Apolipoprotein A-I (apoA-I) induces the translocation of newly synthesized cholesterol as well as caveolin-1 to the cytosolic lipid-protein particle (CLPP) fraction in astrocytes before its appearance in high density lipoprotein generated in the medium (Ito, J., Y. Nagayasu, K. Kato, R. Sato, and S. Yokoyama. 2002. Apolipoprotein A-I induces translocation of cholesterol, phospholipid, and caveolin-1 to cytosol in rat astrocytes. J. Biol. Chem. 277: 7929-7935). We here report the association of signal-related molecules with CLPP. ApoA-I induces rapid translocation of protein kinase Calpha to the CLPP fraction and its phosphorylation in astrocytes. ApoA-I also induces the translocation of phospholipase Cgamma to CLPP. Diacylglyceride (DG) production is increased by apoA-I in the cells, with a maximum at 5 min after the stimulation, and the increase takes place also in the CLPP fraction. An inhibitor of receptor-coupled phospholipase C, U73122, inhibited all the apoA-I-induced events, such as DG production, cholesterol translocation to the cytosol, release of cholesterol, and translocation of protein kinase Calpha into the CLPP fraction. CLPP may thus be involved in the apoA-I-initiated signal transduction in astrocytes that is re...Continue Reading

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Citations

May 14, 2005·Current Opinion in Lipidology·Shinji Yokoyama
Dec 6, 2007·Journal of Neurochemistry·W I SilvaF A González
Sep 29, 2006·Glia·Vedrana MontanaVladimir Parpura
Sep 2, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·W I SilvaI K Salgado-Villanueva
Mar 1, 2006·Journal of Atherosclerosis and Thrombosis·Shinji Yokoyama
Aug 19, 2014·Neurobiology of Disease·David A HottmanLing Li
Nov 15, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Shinji Yokoyama
Sep 6, 2020·Journal of Neurochemistry·Steve PedriniRalph N Martins

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