Apolipoprotein A-I Mimetic Peptide D-4F Reduces Cardiac Hypertrophy and Improves Apolipoprotein A-I-Mediated Reverse Cholesterol Transport From Cardiac Tissue in LDL Receptor-null Mice Fed a Western Diet

Journal of Cardiovascular Pharmacology
Jie HanDong-Mei Miao

Abstract

Epidemiological studies have suggested that hypercholesterolemia is an independent determinant of increased left ventricular (LV) mass. Because high-density lipoprotein and its major protein apolipoprotein A-I (apoA-I) mediate reverse cholesterol transport (RCT) and have cardiac protective effects, we hypothesized that the apoA-I mimetic peptide D-4F could promote RCT in cardiac tissue and decrease cardiac hypertrophy induced by hypercholesterolemia. Low-density lipoprotein receptor-null mice were fed by a Western diet for 18 weeks and then randomized to receive water, or D-4F 0.3 mg/mL, or D-4F 0.5 mg/mL added to drinking water for 6 weeks. After D-4F administration, an increase in high-density lipoprotein cholesterol and a decrease in low-density lipoprotein cholesterol, total cholesterol, and triglyceride in a trend toward dose-responsivity were found in cardiac tissue. Ultrasound biomicroscopy revealed a reduction in LV posterior wall end-diastolic dimension, and an increase in mitral valve E/A ratio and LV ejection fraction. Hematoxylin-eosin staining showed reduced LV wall thickness and myocardial cell diameter. The protein levels of ABCA1 and LXRα were elevated in cardiac tissue of D-4F treated mice compared with the con...Continue Reading

References

Oct 1, 1988·Journal of the American College of Cardiology·I W HammondJ H Laragh
Oct 14, 2000·Annual Review of Cell and Developmental Biology·J J Repa, D J Mangelsdorf
Mar 7, 2001·American Heart Journal·B A VakiliR B Devereux
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jan 14, 2003·Annual Review of Physiology·N Frey, E N Olson
Aug 7, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Scott M GrundyUNKNOWN Coordinating Committee of the National Cholesterol Education Program
Apr 16, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Mohamad NavabAlan M Fogelman
May 2, 2008·Journal of Clinical Lipidology·Mohamad NavabAlan M Fogelman
Aug 26, 2010·Biochimica Et Biophysica Acta·Gordon A Francis
Jun 2, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Satoshi ImaizumiSrinivasa T Reddy
Oct 19, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Mary G Sorci-Thomas, Michael J Thomas
Nov 16, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Edward A FisherJonathan D Smith
Jun 20, 2013·Cholesterol·Anouar Hafiane, Jacques Genest

❮ Previous
Next ❯

Citations

Jan 10, 2020·Journal of the American Heart Association·Soban UmarMansoureh Eghbali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.