Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice.

Molecular Medicine
E KaraviaKyriakos E Kypreos

Abstract

Apolipoprotein A-I (apoA-I) is the main protein of high-density lipoprotein (HDL). We investigated the involvement of apoA-I in diet-induced accumulation of triglycerides in hepatocytes and its potential role in the treatment of nonalcoholic fatty liver disease (NAFLD). ApoA-I-deficient (apoA-I(-/-)) mice showed increased diet-induced hepatic triglyceride deposition and disturbed hepatic histology while they exhibited reduced glucose tolerance and insulin sensitivity. Quantification of FASN (fatty acid synthase) [corrected], DGAT-1 (diacylglycerol O-acyltransferase 1), and PPARγ (peroxisome proliferator-activated receptor γ) mRNA expression suggested that the increased hepatic triglyceride content of the apoA-I(-/-) mice was not due to de novo synthesis of triglycerides. Similarly, metabolic profiling did not reveal differences in the energy expenditure between the two mouse groups. However, apoA-I(-/-) mice exhibited enhanced intestinal absorption of dietary triglycerides (3.6 ± 0.5 mg/dL/min for apoA-I(-/-) versus 2.0 ± 0.7 mg/dL/min for C57BL/6 mice, P < 0.05), accelerated clearance of postprandial triglycerides and a reduced rate of hepatic very low density lipoprotein (VLDL) triglyceride secretion (9.8 ± 1.1 mg/dL/min for ...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R WilliamsonN Maeda
Feb 25, 1972·Biochemical and Biophysical Research Communications·C J FieldingP E Fielding
Jan 1, 1982·CRC Critical Reviews in Biochemistry·J T Sparrow, A M Gotto
Apr 12, 2001·Seminars in Liver Disease·S Chitturi, G C Farrell
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K E KypreosV I Zannis
Jul 27, 2001·Diabetes·G MarchesiniN Melchionda
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Jun 5, 2003·Biochimica Et Biophysica Acta·Mayumi YamamotoTetsurou Handa
Feb 1, 1957·The American Journal of Physiology·M C SCHOTZI H PAGE
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Steven E NissenRichard Kerensky
Jul 16, 2004·The Journal of Clinical Investigation·Jeffrey D Browning, Jay D Horton
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Apr 21, 2005·The Journal of Clinical Investigation·Jenelle M TimminsJohn S Parks
Nov 17, 2005·Annals of Internal Medicine·Masahide HamaguchiKazunori Ida
Dec 13, 2005·Journal of Gastroenterology and Hepatology·Jian-Gao FanShi-Yao Chen
Mar 18, 2006·The Journal of Clinical Investigation·Liam R BrunhamMichael R Hayden
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roberto GambinoGiovanni Musso
Nov 10, 2007·Journal of Lipid Research·Raul D SantosRaul C Maranhão
Aug 30, 2008·The FEBS Journal·Iordanes KaragiannidesKyriakos E Kypreos
Dec 30, 2011·Nature Methods·Matthias H TschöpEric Ravussin

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Citations

Apr 19, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Harry C BlairDionysios J Papachristou
Mar 21, 2017·The Journal of Endocrinology·Nicholaos I PapachristouDionysios J Papachristou
May 18, 2017·Molecular & Cellular Proteomics : MCP·Zhuona RongAiguo Wang
Feb 6, 2019·International Journal of Molecular Sciences·Karen Alejandra Méndez-LaraJosep Julve
Jun 24, 2019·The FEBS Journal·Maria KonstandiFrank J Gonzalez
Nov 29, 2013·The Tohoku Journal of Experimental Medicine·Toyoto IwataKatsuyuki Murata
Mar 22, 2014·Expert Review of Cardiovascular Therapy·Eleni A KaraviaKyriakos E Kypreos
Nov 5, 2015·American Journal of Physiology. Endocrinology and Metabolism·Caterina ConstantinouKyriakos E Kypreos
Nov 27, 2019·Animals : an Open Access Journal From MDPI·Cristian PirasJoëlle Dupont
Dec 15, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Eva XepapadakiKyriakos E Kypreos
Oct 30, 2020·Antioxidants·Laura Inés Elvira-ToralesMaría Jesús Periago-Castón
Mar 19, 2013·Biochemical Pharmacology·Kyriakos E KypreosIordanis Karagiannides
Apr 13, 2021·Frontiers in Oncology·Vasileios LazarisKyriakos E Kypreos
May 20, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Bin ChengJuan Wang
Aug 21, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·José Ytalo Gomes da SilvaMaria Izabel Florindo Guedes

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