Apolipoprotein A-I protection against atherosclerosis is dependent on genetic background

Arteriosclerosis, Thrombosis, and Vascular Biology
Timothy J SontagCatherine A Reardon

Abstract

Inbred mouse strains have different susceptibilities to experimental atherosclerosis. The C57BL/6 strain is among the most sensitive and has, therefore, been the most widely used in atherosclerosis studies, whereas many strains are resistant. The FVB/N strain is highly resistant to atherosclerosis on the apolipoprotein E (apoE)- and low-density lipoprotein (LDL) receptor-deficient backgrounds. High-density lipoprotein and its major apoprotein, apoA-I, have been shown to be protective against atherogenesis on the C57BL/6 background. We here examine the influence of genetic background on the atheroprotective nature of apoA-I. ApoE-deficient/apoA-I-deficient mice were generated in the C57BL/6 and FVB/N strains from apoE-deficient mice. After 6 to 10 weeks on a Western-type diet, plasma lipids and atherosclerotic lesion size were assessed. Macrophage recruitment, cholesterol regulation, and blood monocyte levels were examined as potential mechanisms driving lesion size differences. FVB/N knockout mice had higher plasma very-LDL/LDL cholesterol than their C57BL/6 counterparts. ApoA-I deficiency decreased very-LDL/LDL cholesterol in C57BL/6 mice but not in FVB/N mice. FVB/N single and double knockout mice had less lesion than C57BL/6...Continue Reading

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Citations

Jun 3, 2015·Current Cardiology Reports·Bernd Hewing, Ulf Landmesser
Jan 7, 2015·Journal of Lipid Research·Stela Z BerishaJonathan D Smith
Jul 19, 2015·Journal of the American Heart Association·Paulette A KrishackCatherine A Reardon
Feb 21, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert Terkeltaub
Jul 22, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Alan DaughertyUNKNOWN American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Basic Cardiovascular
Jul 22, 2017·Circulation Research·Alan DaughertyUNKNOWN American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Basic Cardiovascular
Jul 22, 2017·Current Opinion in Lipidology·Godfrey S Getz, Catherine A Reardon
Aug 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Steven TimmermansClaude Libert
Jun 25, 2019·Frontiers in Pharmacology·Godfrey S Getz, Catherine A Reardon
Jul 22, 2021·Cell Metabolism·Robert H EckelIra J Goldberg

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