Abstract
Inbred mouse strains have different susceptibilities to experimental atherosclerosis. The C57BL/6 strain is among the most sensitive and has, therefore, been the most widely used in atherosclerosis studies, whereas many strains are resistant. The FVB/N strain is highly resistant to atherosclerosis on the apolipoprotein E (apoE)- and low-density lipoprotein (LDL) receptor-deficient backgrounds. High-density lipoprotein and its major apoprotein, apoA-I, have been shown to be protective against atherogenesis on the C57BL/6 background. We here examine the influence of genetic background on the atheroprotective nature of apoA-I. ApoE-deficient/apoA-I-deficient mice were generated in the C57BL/6 and FVB/N strains from apoE-deficient mice. After 6 to 10 weeks on a Western-type diet, plasma lipids and atherosclerotic lesion size were assessed. Macrophage recruitment, cholesterol regulation, and blood monocyte levels were examined as potential mechanisms driving lesion size differences. FVB/N knockout mice had higher plasma very-LDL/LDL cholesterol than their C57BL/6 counterparts. ApoA-I deficiency decreased very-LDL/LDL cholesterol in C57BL/6 mice but not in FVB/N mice. FVB/N single and double knockout mice had less lesion than C57BL/6...Continue Reading
References
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·P W WilsonW P Castelli
Oct 1, 1985·Atherosclerosis·B PaigenP Holmes
Aug 1, 1994·The Journal of Clinical Investigation·C PásztyE M Rubin
Jul 1, 1993·Lipids·P M NishinaB Paigen
May 26, 2001·The American Journal of Cardiology·W E Boden
Aug 9, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Daniel TeupserJan L Breslow
Aug 23, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Ryan E MooreDaniel J Rader
Aug 26, 2003·The American Journal of Pathology·Manal ZabalawiMary G Sorci-Thomas
Sep 10, 2005·Circulation Research·Ryan E MooreDaniel J Rader
Feb 24, 2006·Atherosclerosis·Olga SteinYechezkiel Stein
Dec 26, 2006·The Journal of Biological Chemistry·Michael M BeyeaMurray W Huff
Jan 30, 2007·Nature Reviews. Immunology·Frank Rosenbauer, Daniel G Tenen
Oct 15, 2008·Circulation·Laurent Yvan-CharvetAlan R Tall
Oct 30, 2008·Journal of Lipid Research·Paul A VanderLaanGodfrey S Getz
Sep 29, 2009·The Journal of Biological Chemistry·Chongren TangJohn F Oram
May 22, 2010·Science·Laurent Yvan-CharvetAlan R Tall
Jul 24, 2010·Journal of Lipid Research·Xuewei ZhuJohn S Parks
Jan 14, 2011·The New England Journal of Medicine·Amit V KheraDaniel J Rader
Mar 10, 2012·Journal of Lipid Research·Timothy J SontagGodfrey S Getz
Aug 7, 2012·Cell Stem Cell·Marit WesterterpLaurent Yvan-Charvet
Aug 25, 2012·Genome Biology·Kim WongThomas M Keane
Oct 2, 2012·Circulation Research·Chieko Mineo, Philip W Shaul
Oct 16, 2012·Circulation Research·Bernd HewingEdward A Fisher
Dec 12, 2012·Trends in Endocrinology and Metabolism : TEM·Oliver Soehnlein, Filip K Swirski
Jul 3, 2013·Journal of Lipid Research·Timothy J SontagCatherine A Reardon
Citations
Sep 30, 2015·Stem Cells·Aparna VasanthakumarLucy A Godley
Mar 13, 2016·Biochimica Et Biophysica Acta·Miriam Lee-RueckertPetri T Kovanen
Jun 3, 2015·Current Cardiology Reports·Bernd Hewing, Ulf Landmesser
Jan 7, 2015·Journal of Lipid Research·Stela Z BerishaJonathan D Smith
Dec 18, 2015·Journal of Lipid Research·Nathalie PamirJay W Heinecke
Mar 5, 2018·Journal of the American Heart Association·Ibra S FancherIrena Levitan
Jul 19, 2015·Journal of the American Heart Association·Paulette A KrishackCatherine A Reardon
Feb 21, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert Terkeltaub
Mar 14, 2018·Hypertension·T Michael De SilvaFrank M Faraci
Jul 22, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Alan DaughertyUNKNOWN American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Basic Cardiovascular
Jul 22, 2017·Circulation Research·Alan DaughertyUNKNOWN American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Basic Cardiovascular
Jul 22, 2017·Current Opinion in Lipidology·Godfrey S Getz, Catherine A Reardon
Aug 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Steven TimmermansClaude Libert
Jun 25, 2019·Frontiers in Pharmacology·Godfrey S Getz, Catherine A Reardon
Jan 11, 2017·Acta Biochimica Et Biophysica Sinica·Jiyang LiLi Ye
Jul 22, 2021·Cell Metabolism·Robert H EckelIra J Goldberg