Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation.

Endocrinology
Qi ZhuChunmin C Lo

Abstract

Apolipoprotein A-IV (ApoA-IV) synthesized by the gut regulates lipid metabolism. Sympathetic innervation of adipose tissues also controls lipid metabolism. We hypothesized that ApoA-IV required sympathetic innervation to increase fatty acid (FA) uptake by adipose tissues and brown adipose tissue (BAT) thermogenesis. After 3 weeks feeding of either a standard chow diet or a high-fat diet (HFD), mice with unilateral denervation of adipose tissues received intraperitoneal administration of recombinant ApoA-IV protein and intravenous infusion of lipid mixture with radioactive triolein. In chow-fed mice, ApoA-IV administration increased FA uptake by intact BAT but not the contralateral denervated BAT or intact white adipose tissue (WAT). Immunoblots showed that, in chow-fed mice, ApoA-IV increased expression of lipoprotein lipase and tyrosine hydroxylase in both intact BAT and inguinal WAT (IWAT), while ApoA-IV enhanced protein levels of β3 adrenergic receptor, adipose triglyceride lipase, and uncoupling protein 1 in the intact BAT only. In HFD-fed mice, ApoA-IV elevated FA uptake by intact epididymal WAT (EWAT) but not intact BAT or IWAT. ApoA-IV increased sympathetic activity assessed by norepinephrine turnover (NETO) rate in BAT ...Continue Reading

References

Apr 1, 1990·The American Journal of Physiology·L CampsT Olivecrona
May 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G M Dallinga-ThieA Van Tol
Jan 1, 1971·Annual Review of Biochemistry·P B Molinoff, J Axelrod
May 1, 1982·The Journal of Clinical Investigation·C N Sadur, R H Eckel
May 1, 1982·The Journal of Clinical Investigation·J B YoungL Landsberg
Feb 12, 1998·The Journal of Clinical Investigation·C A Siegrist-KaiserC A Meier
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T J Kalogeris, R G Painter
Mar 29, 2001·Annual Review of Public Health·S A FrenchR W Jeffery
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M LiuP Tso
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S F Morrison
Sep 21, 2002·Diabetologia·K N Frayn
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Ayanna S AugustusIra J Goldberg
Jan 22, 2003·Physiology & Behavior·Min LiuPatrick Tso
Jun 5, 2003·Journal of Lipid Research·Benjie EzehFlorian Kronenberg
Nov 12, 2003·Experimental Biology and Medicine·Min LiuPatrick Tso
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
May 12, 2004·Physiology & Behavior·Haifei ShiTimothy J Bartness
Nov 20, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Haifei ShiTimothy J Bartness
Nov 20, 2004·Science·Robert ZimmermannRudolf Zechner
Jul 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dawn M PennRuth B S Harris
Nov 1, 2006·Vascular Pharmacology·Allan D Callow
Oct 31, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mathieu LaplanteYves Deshaies
Nov 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chun-Min LoPatrick Tso
Sep 15, 2009·Molecular and Cellular Endocrinology·Timothy J BartnessC K Song
Nov 13, 2010·Annals of the New York Academy of Sciences·A KalsbeekE Fliers
Jan 25, 2011·Nature Medicine·Alexander BarteltJoerg Heeren
Sep 1, 2011·Diabetes Research and Clinical Practice·George DimitriadisSotirios A Raptis
Dec 29, 2011·The Journal of Clinical Investigation·Joshua P ThalerMichael W Schwartz
Dec 31, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alison B KohanPatrick Tso
May 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Fei WangPatrick Tso
Jun 14, 2013·Frontiers in Physiology·Sam Virtue, Antonio Vidal-Puig
Nov 29, 2013·Journal of Lipid Research·Janine J GeerlingPatrick C N Rensen

❮ Previous
Next ❯

Citations

Jan 31, 2021·International Journal of Molecular Sciences·Sydney PenceChunmin C Lo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.