PMID: 2106917Mar 12, 1990Paper

Apolipoprotein AIMilano. Partial lecithin:cholesterol acyltransferase deficiency due to low levels of a functional enzyme

Biochimica Et Biophysica Acta
G FranceschiniM C Cheung

Abstract

The cholesterol esterification process was analyzed in 19 carriers of the apolipoprotein AIMilano (AIM) variant and in 19 age-sex matched controls by measuring lecithin:cholesterol acyltransferase (LCAT) mass, activity (i.e., cholesterol esterification with a standard proteoliposome substrate) and cholesterol esterification rate (i.e., cholesterol esterification in the presence of the endogenous substrate). The AIM subjects had lower LCAT mass (3.30 +/- 0.85 micrograms/ml), activity (71.1 +/- 36.4 nmol/ml per h) and cholesterol esterification rate (23.6 +/- 12.5 nmol/ml per h) compared to controls (5.22 +/- 0.74 micrograms/ml, 121.6 +/- 54.6 nmol/ml per h and 53.6 +/- 29.9 nmol/ml per h, respectively). The specific LCAT activity, i.e., LCAT activity per microgram of LCAT, was similar in the two groups, indicating that the LCAT protein in the AIM carriers is structurally and functionally normal. However, the specific cholesterol esterification rate was 23% lower in the AIM subjects (8.03 +/- 6.01 nmol/h per microgram) compared to controls (10.49 +/- 5.86 nmol/h per microgram; P less than 0.05). The capacity of HDL3, purified from both AIM and control plasma, to act as substrates for cholesterol esterification was similar, thus s...Continue Reading

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Citations

Jan 1, 1994·Pharmacology & Therapeutics·G FranceschiniL Calabresi
Jul 30, 2014·Biochimica Et Biophysica Acta·Laura CalabresiGuido Franceschini
Apr 5, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Monica GomaraschiLaura Calabresi
Apr 20, 2014·Journal of Cardiovascular Pharmacology and Therapeutics·Fang TianPrediman K Shah
Nov 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·T MurakamiG Franceschini
Sep 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J EmmerichH B Brewer
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·M Tilly-KiesiM R Taskinen
Oct 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·G FranceschiniC R Sirtori
Apr 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·L CalabresiG Franceschini
May 14, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·G FranceschiniF Bernini
Feb 6, 2018·Scientific Reports·Massimiliano RuscicaMonica Gomaraschi
Apr 8, 1999·Progress in Lipid Research·A Jonas
May 17, 1995·Biochimica Et Biophysica Acta·C G Brouillette, G M Anantharamaiah

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