PMID: 9533408Apr 9, 1998Paper

Apolipoprotein AIV codon 360 mutation increases with human aging and is not associated with Alzheimer's disease

Neuroscience Letters
A MerchedS Visvikis

Abstract

In order to evaluate genetic apolipoprotein polymorphisms as risk factors for Alzheimer's disease (AD), we studied apolipoprotein (apo) AIV after apoE, an apolipoprotein also present in the brain. The allelic distribution of apoAIV codon 360 polymorphism was no different in AD group (n = 120) compared with elderly healthy individuals (n = 119). Surprisingly, this polymorphism was over-represented (11.40%, vs. 5.7% P < 0.005) in all these aged subjects (74.29 +/- 8.46 years) and independently of the clinical and mental status compared with the younger population (39.00 +/- 9.69 years) of the same regional recruitment. These results suggest that the apoAIV (360:His) allele could be a marker of aging and longevity.

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Citations

Nov 18, 2004·Biogerontology·B BessenyeiI Semsei
Mar 12, 2004·Mechanisms of Ageing and Development·Francesco PanzaVincenzo Solfrizzi
May 12, 2001·Mechanisms of Ageing and Development·G De BenedictisA I Yashin
Jan 27, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M Daniele Fallin, Amy Matteini
Mar 16, 2005·Current Opinion in Lipidology·Jose M Ordovas, Vincent Mooser
Apr 5, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·T F EjchelMarília de Arruda Cardoso Smith
Sep 6, 2020·Journal of Neurochemistry·Steve PedriniRalph N Martins
Mar 2, 2011·The American Journal of Pathology·Yujie CuiYongzhang Luo

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