PMID: 9532235Apr 9, 1998Paper

Apolipoprotein and lipid abnormalities in chronic liver failure

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
A C SpósitoJ A Ramires

Abstract

Total serum lipids, as well as apolipoproteins A-I (apo A-I) and B (apo B), were determined in 74 patients with chronic liver failure without cholestasis and in 82 normal subjects. The VLDL, LDL and HDL lipid fractions were reduced in the liver failure group by 36%, 24% and 46%, respectively (P < 0.001). Apolipoproteins A-I and B were also reduced by 26% and 25%, respectively (P < 0.001). However, the reduction of HDL cholesterol (HDLc) was more pronounced than that of apo A-I and the HDLc:apo A-I ratio was significantly lower in the liver failure group. After separating these patients into groups with plasma albumin lower than 3.0, between 3.0 and 3.5, and higher than 3.5 g/dl, the HDLc:apo A-I ratio was proportional to plasma albumin, but the correlation was not statistically significant. When these patients were separated by the Child classification of liver function, there was a correlation between the HDLc:apo A-I ratio and liver function. The differences in the HDLc:apo A-I ratio between the Child groups B and C, and A and C were statistically significant (P < 0.05). We conclude that there is a more pronounced reduction in HDL cholesterol than in apo A-I in liver failure patients. Therefore, the HDLc:apo A-I ratio is a ma...Continue Reading

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Citations

Mar 1, 2007·Journal of Clinical Lipidology·Ronald B Goldberg, Armando J Mendez
Apr 3, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kymberly D WattMichael R Charlton
Mar 1, 2006·International Journal of Cardiology·Roberto OtsuboJosé Antonio Franchini Ramires
Jun 4, 2017·International Journal of Cancer. Journal International Du Cancer·Paul NderituMieke Van Hemelrijck
Jun 2, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·M IrshadY K Joshi
Nov 28, 2017·Digestive Diseases and Sciences·Graziella PriviteraFrancesco Purrello
Nov 18, 2015·World Journal of Gastroenterology : WJG·En-Qiang ChenHong Tang
Nov 23, 2016·Journal of Pediatric Gastroenterology and Nutrition·Irena JankowskaPiotr Socha

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