Apolipoprotein B-48 as a determinant of endothelial function in obese subjects with type 2 diabetes mellitus: effect of fenofibrate treatment

Atherosclerosis
D C ChanG F Watts

Abstract

Elevated triglyceride-rich lipoproteins may contribute to endothelial dysfunction in obese diabetic subjects. We investigated the association between plasma concentrations of chylomicron-related particles and endothelial function, and the corresponding responses to fenofibrate treatment. Plasma apolipoprotein (apo) B-48 and remnant-like particle (RLP)-cholesterol concentrations were measured in 28 obese subjects with T2DM. Flow-mediated endothelium-dependent dilation (FMD) and glyceryl-trinitrate mediated dilatation (GTNMD) in the brachial artery during reactive hyperaemia were examined by high-resolution ultrasound technique. In univariate analysis, plasma apoB-48 and RLP-cholesterol concentrations were inversely associated with brachial artery FMD (r = -0.425 and -0.423, respectively, P<0.05), but not with GTNMD. In regression models including BMI and HOMA score, plasma apoB-48 was an independent predictors (P<0.05) of brachial artery FMD (β coefficient = -0.384). Replacing HOMA-IR score with plasma triglyceride, adiponectin or CRP concentrations did not alter the findings. The subjects were then randomized to a 12-week treatment period of either 200mg micronized fenofibrate or matching placebo. Compared with the placebo grou...Continue Reading

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Citations

May 19, 2012·Current Opinion in Lipidology·Jing PangGerald F Watts
Apr 19, 2013·Current Opinion in Lipidology·John S Millar
Sep 12, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Xuemei YuTong Zhu
Dec 27, 2013·Journal of Diabetes Research·Suzanne M EkenLars Maegdefessel
Feb 11, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jan BorénMarja-Riitta Taskinen
Apr 18, 2013·Current Opinion in Cardiology·Genovefa Kolovou, Teik Chye Ooi
Feb 19, 2014·Atherosclerosis·Changting XiaoGary F Lewis
May 26, 2015·Clinical Lipidology·Jixin ZhongSanjay Rajagopalan
Nov 26, 2016·Food & Function·Sergio Montserrat-de la PazFrancisco J G Muriana
Nov 21, 2017·Molecular Medicine Reports·Puhong ZhangYao Zhang

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