PMID: 11311225Apr 20, 2001Paper

Apolipoprotein B as the best predictor of coronary artery disease in Iranian normolipidemic patients

Clinical Biochemistry
M HaidariM Doosti

Abstract

A relatively high proportion of Iranian patients with coronary artery disease (CAD) have normal levels of traditional lipid risk factors and show early onset of CAD. In this study we examined the roles of apolipoprotein B (apoB), apolipoprotein AI (apoAI) and lipoprotein (a) [LP(a)] in predicting coronary heart disease in normolipidemic patients and those with premature CAD (age < or = 50). Serum levels of apoB, apoAI, and LP(a) were determined in a total of 567 Iranian patients who were candidates for coronary angiography. A subgroup of 142 patients (93 males, 49 females) with normal levels of classical lipid risk factors, and a subgroup of patients (130 males, 71 females) with age below 50 years were separately assessed for coronary risk factors. ApoB concentrations were significantly higher in patients with CAD (CAD+) relative to patients without CAD (CAD-) in the two subgroups. Multiple logistic regression after controlling for age and others risk factors showed apoB as the best determinant of CAD in the normolipidemic subgroup (OR, 4.3, p < 0.001) and in the men aged < or = 50 (OR, 5.7, p < 0.001). ApoB was the best predictor of CAD in a subgroup of very young patients (age < or = 40, n = 77, OR, 8.6, p < 0.009). There was...Continue Reading

References

Mar 1, 1976·Metabolism: Clinical and Experimental·J D BrunzellE L Bierman
Oct 1, 1992·The American Journal of Cardiology·E A EnasJ L Mehta
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J de GraafA F Stalenhoef
Jun 1, 1991·The American Journal of Cardiology·J J GenestE J Schaefer
Sep 1, 1984·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·H SchriewerH Schulte
Feb 1, 1983·The American Journal of Cardiology·G G Gensini
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A SnidermanP O Kwiterovich
May 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·K J Williams, I Tabas
Sep 30, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·J H ContoisE J Schaefer
Dec 13, 1996·International Journal of Cardiology·R GuptaH S Wasir
Apr 1, 1997·The American Journal of Cardiology·J M SullivanK B Ramanathan
Apr 18, 1997·International Journal of Cardiology·M S ElisafD A Sideris
Mar 11, 1998·Circulation·K S Reddy, S Yusuf
Jul 22, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·H T WesterveldD W Erkelens
Nov 4, 2000·Atherosclerosis·F PerretL Kappenberger

❮ Previous
Next ❯

Citations

May 26, 2006·The British Journal of Ophthalmology·N DashtiC A Curcio
Aug 2, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Mehdi RasouliVahid Mokhberi
Jul 27, 2010·Clinical Biochemistry·Asad Vaisi-RayganiTayebeh Pourmotabbed
Apr 9, 2015·Disease Markers·Anastasiya M KanevaJon Ø Odland
Dec 22, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·James P CorsettiCharles E Sparks
Feb 11, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M SolatiF Azizi
Jun 29, 2021·International Journal of Clinical Practice·Mohammad Haji AghajaniMahmoud Yousefifard

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.