Apolipoprotein B/apolipoprotein A-I in relation to the metabolic syndrome and change in carotid artery intima-media thickness during 3 years in middle-aged men

Stroke; a Journal of Cerebral Circulation
K WallenfeldtB Fagerberg

Abstract

The apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio is a measure of the relationship between different lipoprotein particles and a powerful predictor of coronary death. The aim was to examine whether apoB/apoA-I was associated with the metabolic syndrome (MetS) at baseline and also with the future change in carotid artery intima-media thickness (IMT). In 313 58-year-old men, carotid artery IMT was measured bilaterally by high-resolution B-mode ultrasound at baseline and after 3 years of follow-up. Serum apolipoprotein concentrations and the components of MetS were measured at study entry. ApoB/apoA-I showed statistically significant associations with body mass index, waist-to-hip ratio, high-density lipoprotein (HDL) cholesterol, triglycerides, low-density lipoprotein (LDL) particle size, insulin, and diastolic blood pressure. Two thirds of the patients with MetS had high apoB/apoA-I ratios (>0.90) compared with one third of those without the syndrome (P<0.001). The IMT change was associated with apoB, total cholesterol, LDL cholesterol, triglycerides, and inversely with HDL cholesterol and LDL particle size at entry, and there was a strong colinearity between these variables. The subjects with apoB/apoA-I above the f...Continue Reading

References

May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults

❮ Previous
Next ❯

Citations

Aug 19, 2008·Current Atherosclerosis Reports·H Robert Superko, Radhika R Gadesam
Feb 15, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A OnatS Albayrak
Apr 5, 2012·Metabolic Syndrome and Related Disorders·Alireza EsteghamatiManouchehr Nakhjavani
Nov 13, 2007·Current Opinion in Lipidology·Allan D Sniderman, May Faraj
Mar 13, 2008·Diabetes, Obesity & Metabolism·M Andrikoula, I F W McDowell
Oct 16, 2007·International Journal of Clinical Practice·M Rizzo, K Berneis
Nov 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Esther M M OoiP Hugh R Barrett
Jan 31, 2014·Journal of Atherosclerosis and Thrombosis·Jin-Man JungMoon Ho Park
Jun 9, 2007·Current Opinion in Cardiology·Göran Walldius, Ingmar Jungner
Oct 7, 2010·Indian Journal of Pediatrics·S Savas ErdeveZeynep Biyikli
Feb 2, 2006·Annals of Medicine·Enzo Bonora
Jan 26, 2016·Metabolic Syndrome and Related Disorders·Harry Robberecht, Nina Hermans
May 13, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kaspar BerneisGiovam Battista Rini
Apr 21, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Manfredi RizzoJelena Vekic
Mar 13, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Brandalyn C RiedelRoberta Diaz Brinton
Nov 27, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Li TianLianqun Jia
Jul 17, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Göran Walldius, Ingmar Jungner
Mar 24, 2007·Metabolism: Clinical and Experimental·Gaetano VaudoElmo Mannarino
Jun 25, 2005·Obesity Research·Esther M M OoiP Hugh R Barrett
Aug 23, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·T J LyonsUNKNOWN DCCT/EDIC Research Group
Feb 16, 2006·Journal of Internal Medicine·G WalldiusI Jungner
Nov 3, 2006·Diabetes/metabolism Research and Reviews·Manfredi Rizzo, Kaspar Berneis
Apr 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·E M DahlénC J Ostgren
Dec 1, 2006·The American Journal of Cardiology·Justo Sierra-JohnsonFrancisco Lopez-Jimenez
Jun 2, 2006·Disease-a-month : DM·Ambika Babu, Leon Fogelfeld
May 10, 2006·International Journal of Cardiology·Jae-Youn MoonNamsik Chung
Feb 24, 2006·European Journal of Internal Medicine·Manfredi Rizzo, Kaspar Berneis
Nov 17, 2009·Metabolism: Clinical and Experimental·Jong Suk ParkHyun Chul Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.