Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for lung cancer: A marker phase I trial

Thoracic Cancer
Hui-Ling KoShang-Jyh Kao

Abstract

Tumor cells continuously evolve over time in response to host pressures. However, explanations as to how tumor cells are influenced by the inflammatory tumor microenvironment over time are, to date, poorly defined. We hypothesized that prognostic biomarkers could be obtained by exploring the expression of inflammation-associated genes between early and late stage lung cancer tumor samples. Candidate inflammation-associated genes, apolipoprotein C-1 (APOC1), MMP1, KMO)1, CXCL5, CXCL)7, IL-1α, IL-1β, TNF-α and IL-6 were verified by real-time quantitative polymerase chain reaction. Gene expression profiles and immunofluorescence staining of 30 lung cancer tissues were compared. Expressions of APOC1 and IL-6 mRNA on tumor tissues in late stage disease were significantly higher than in early stage lung cancer samples. Immunofluorescence staining of tumor samples showed that the expression of APOC1 gradually increased from early to late stage in lung cancer patients. The expression levels of IL-6 and APOC1 in tumor samples were positively correlated; however, no prognostic value of APOC1 can be identified in serum samples. We found that the level of tumor APOC1 was highly expressed in late stage lung cancer. Further research is warra...Continue Reading

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Citations

May 3, 2018·Journal of Biochemical and Molecular Toxicology·Wei-Peng SuDong Wang
Jun 28, 2019·Lab on a Chip·Luca DigiacomoGiulio Caracciolo
Oct 2, 2019·Cancer Medicine·Liwen RenGuanhua Du
Nov 30, 2019·International Journal of Molecular Sciences·Elena V Fuior, Anca V Gafencu
May 23, 2019·British Journal of Cancer·Sasagu KurozumiEmad A Rakha
Jul 20, 2019·Medical Oncology·Ali Mohamed AlshabiChanabasayya Vastrad
Aug 6, 2020·Journal of Lipid Research·Zoe HallJulian L Griffin
Dec 12, 2020·The Kaohsiung Journal of Medical Sciences·Hai-Jun WangXian-Zhou Jiang
Jan 21, 2021·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Songwei GeZiv Bar-Joseph

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