Jun 1, 2020

Apolipoprotein CIII predicts cardiovascular events in patients with coronary artery disease: a prospective observational study

Lipids in Health and Disease
Julius L KatzmannUlrich Laufs

Abstract

Apolipoprotein CIII (apoCIII) is associated with triglyceride-rich lipoprotein metabolism and has emerged as independent marker for risk of cardiovascular disease. The objective was to test whether apoCIII is regulated postprandially and whether apoCIII concentrations in native and chylomicron-free serum predict future cardiovascular events in patients with stable coronary artery disease (CAD). ApoCIII concentrations were measured in native and chylomicron-free serum in the fasting state and after a standardized oral fat load test in 195 patients with stable CAD. Clinical follow-up was 48 months. Chylomicron-free serum was prepared by ultracentrifugation (18,000 rpm, 3 h). The log-rank test and Cox regression analyses were used to investigate the association of apoCIII with recurrent cardiovascular events. Of the 195 patients included, 92 had a cardiovascular event, and 103 did not. 97% were treated with a statin. No significant changes in apoCIII concentration were observed after the oral fat load test. The apoCIII concentration was associated with event-free survival independent of conventional risk factors. This association reached statistical significance only for apoCIII concentration measured in chylomicron-free serum (ha...Continue Reading

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Mentioned in this Paper

Serum
APOC3
Triglyceride-rich Lipoprotein Particle Clearance
Clinical Trials
Oral Cavity
Risk Assessment
Follow-up
Objective (Goal)
Regression Analysis
Chylomicrons Measurement

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