Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson's Disease: A Cross-Sectional Study

Parkinson's Disease
Andreas WaldnerMarialuisa Gandolfi

Abstract

Apolipoprotein D (ApoD), a lipocalin transporter of small hydrophobic molecules, plays an important role in several neurodegenerative diseases. ApoD is expressed in and secreted from a variety of peripheral and brain tissues. Increments of ApoD have been reported in relation with oxidative stress conditions, aging, and degeneration in the nervous system. Preliminary findings support the role of ApoD in neuroprotection. However, its role in PD remains unclear. To date, no studies have been performed on the relationship between ApoD in the blood and PD, as neurodegenerative pathology related to oxidative damage. We investigated the concentration of ApoD in the blood of healthy control subjects and PD patients with mild-to-moderate neurological impairment. ApoD plasma levels were measured using sandwich enzyme-linked immunosorbent assays (ELISA) in 90 healthy subjects (aging-analysis cohort) and in 66 PD patients at different stages compared with 19 age-matched healthy subjects. Significant age-related increase of ApoD was detected in subjects older than 65 years of age (p < 0.002). In PD patients, a significant increase in ApoD plasma concentration was found compared with healthy subjects of the same age (p < 0.05). ApoD and PD s...Continue Reading

References

Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S G SimonsonC A Piantadosi
Oct 21, 1998·Neuroscience Letters·A NavarroE del Valle
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Nov 4, 2000·Biochimica Et Biophysica Acta·E RassartR Milne
Mar 21, 2003·Immunology and Allergy Clinics of North America·Helle Brüünsgaard, Bente Klarlund Pedersen
Jul 9, 2003·Annals of the New York Academy of Sciences·Stanley Fahn
Sep 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Eva del ValleJorge Tolivia
Nov 19, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Elizabeth A ThomasJ Gregor Sutcliffe
Jan 27, 2006·Histology and Histopathology·C OrdoñezJ Tolivia
Mar 18, 2006·Nature Reviews. Genetics·Matthew James Farrer
Feb 7, 2007·Journal of Neuroscience Research·Yusaku NakabeppuKunihiko Sakumi
Nov 28, 2007·Annual Review of Pathology·Bruce A YanknerPatrick Loerch
Oct 3, 2008·PloS One·Patrick M LoerchBruce A Yankner
Dec 10, 2009·Neurochemical Research·Ho-Joo LeeAbesh Kumar Bhattacharjee
Mar 26, 2010·Nature·Nicholas A BishopBruce A Yankner
Jul 20, 2010·Free Radical Biology & Medicine·David de Gonzalo-CalvoAna Coto-Montes
Mar 27, 2012·Cellular and Molecular Life Sciences : CMLS·Antero SalminenAnu Kauppinen
Feb 5, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Fabio Blandini
Mar 13, 2014·Neurobiology of Aging·Sarah DassatiRüdiger Schweigreiter
Aug 15, 2014·Frontiers in Aging Neuroscience·Rakhee KrishnaAhmed A Moustafa
Nov 27, 2014·Frontiers in Cellular Neuroscience·Nadia García-MateoDiego Sanchez
Apr 15, 2015·Experimental Gerontology·Diego SanchezMaria D Ganfornina
Mar 23, 2017·CNS & Neurological Disorders Drug Targets·Stefania BrotiniLeonello Guidi
Oct 31, 2017·Free Radical Biology & Medicine·Vittorio CalabreseClaudio Franceschi

❮ Previous
Next ❯

Citations

Jan 10, 2019·BMC Evolutionary Biology·Langyu Gu, Canwei Xia
Feb 14, 2020·Scientific Reports·Melissa S RotunnoS Pablo Sardi
Dec 31, 2020·Antioxidants·Cadiele Oliana ReichertSergio P Bydlowski
Oct 26, 2021·Frontiers in Physiology·Diego Sanchez, Maria D Ganfornina

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.