Apolipoprotein E alleles in women with polycystic ovary syndrome

Fertility and Sterility
Seppo HeinonenS Saarikoski

Abstract

To investigate the frequency of apoE alleles among women with polycystic ovary syndrome. Retrospective case-control study. University-based endocrinology/infertility clinic. Healthy fertile women (n = 91) and women with a diagnosis of polycystic ovary syndrome (n = 58). None. The presence of the three most common apoE alleles (epsilon2, epsilon3, and epsilon4) determined by polymerase chain reaction-restriction fragment length polymorphism in the two groups and in the general population in our area. The frequency of the apo epsilon4 allele was 17.2% among women with polycystic ovary syndrome and was 18.7% among healthy fertile women, which is close to the rate in the general population in our area (19%). None of the apoE genotypes (Fisher's exact test; P=.71) or alleles (P=.78) was significantly overrepresented, and the homozygous genotype epsilon4 was not associated with the clinical disease. The observed profiles of allele and genotype frequencies confirm the equilibrium state between apoE polymorphism and polycystic ovary syndrome and suggest that apoE does not play a major role in the development of hyperlipidemia in the group of women with polycystic ovary syndrome.

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Citations

Dec 6, 2008·Journal of Assisted Reproduction and Genetics·Sevki CetinkalpCandeger Yilmaz
Jun 12, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Hong-Wei LiuYing Wang
Feb 17, 2007·Clinical Obstetrics and Gynecology·Marie Nam Menke, Jerome F Strauss
Apr 29, 2014·Reproductive Biomedicine Online·Izhar Ben-Shlomo, Johnny S Younis
Jan 11, 2007·The Journal of Clinical Endocrinology and Metabolism·Michael P WhyteChad Deal
Nov 25, 2004·Endocrine Reviews·Héctor F Escobar-MorrealeJosé L San Millán
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Alejandro GonzalezAgustín Ruiz

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