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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Nature Reviews. Neurology

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Yu YamazakiGuojun Bu

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Abstract

Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2 allele conferring a decreased risk relative to the common APOE*ε3 allele. Strong evidence from ...read more

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Alleles
Alzheimer's Disease
Amyloid
Apolipoprotein E
Brain
Pharmaceutical Preparations
Nerve Degeneration
Pathologic Processes
Pathology
Synapses
54
2
3
95
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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Nature Reviews. Neurology

Invalid date

Yu YamazakiGuojun Bu

PMID: 31367008

DOI: 10.1038/s41582-019-0228-7

Abstract

Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2 allele conferring a decreased risk relative to the common APOE*ε3 allele. Strong evidence from ...read more

Mentioned in this Paper

Alleles
Alzheimer's Disease
Amyloid
Apolipoprotein E
Brain
54
2
3
95

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Paper Details
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  • Citations1
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