Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults

International Journal of Geriatric Psychiatry
Shraddha SapkotaRoger A Dixon

Abstract

Recent research has linked psychological (personality) factors and specific genetic risk polymorphisms to performance on neurocognitive phenotypes. We examined whether episodic or semantic memory performance is associated with (a) three personality traits (i.e. neuroticism, extraversion, and openness to experience), (b) two neurodegenerative-related polymorphisms (i.e. Apolipoprotein E (APOE; rs7412; rs429358), Clusterin (CLU; rs11136000)), and (c) cross-domain risk interactions (magnification effects). Linear growth models were examined to test independent associations between personality traits and declarative memory performance, and potential interaction effects with APOE and CLU genetic risk. Normal older adults (n = 282) with personality and genetic data from the Victoria Longitudinal Study were included at baseline and for up to 14 years of follow-up. First, we observed that higher openness to experience levels were associated with better episodic and semantic memory. Second, three significant gene × personality interactions were associated with poorer memory performance at baseline. These synergistic effects are: (a) APOE allelic risk (ε4+) carriers with lower openness to experience levels, (b) CLU (no risk: T/T) homozyg...Continue Reading

References

Jun 1, 1996·Journal of Neurochemistry·S D HarrA J Mendez
Oct 25, 1996·Science·M GallagherM J West
Jan 15, 1998·The New England Journal of Medicine·B S McEwen
Feb 19, 2000·International Journal of Geriatric Psychiatry·W Meins, J Dammast
Apr 26, 2001·Neurology·E R PeskindM A Raskind
Aug 25, 2001·Journal of Personality and Social Psychology·Paul T CostaRobert R McCrae
May 6, 2003·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Brent J SmallUNKNOWN Victoria Longitudinal Study
May 15, 2003·Experimental Aging Research·Marko JelicicJelle Jolles
Mar 31, 2004·Trends in Cognitive Sciences·Ian J DearyJohn M Starr
Dec 9, 2004·Psychology and Aging·Brent J SmallLars Bäckman
May 3, 2005·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Michael J Shanahan, Scott M Hofer
Jan 5, 2007·Neuropsychology·Anthony F JormSimon Easteal
Jan 30, 2007·Journal of Occupational Health Psychology·Sharon Grant, Janice Langan-Fox
Dec 15, 2007·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Janet M DuchekRandy Larsen
Jan 21, 2009·Neurology·H-X WangL Fratiglioni
Feb 20, 2009·Frontiers in Neuroscience·Ulman LindenbergerLars Bäckman
May 21, 2009·Molecular Psychiatry·J BelskyR Williams
Aug 5, 2009·Brain Research Reviews·Tapio NuutinenAntero Salminen
Dec 15, 2010·Developmental Psychology·Andrea Soubelet, Timothy A Salthouse
Apr 16, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Lyzel S Elias-SonnenscheinPieter Jelle Visser
May 4, 2011·Nature Reviews. Neurology·Amy L Byers, Kristine Yaffe
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Meredith N BraskiePaul M Thompson
Aug 16, 2011·Trends in Cognitive Sciences·Sarah E Harris, Ian J Deary
Feb 24, 2012·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Eileen K Graham, Margie E Lachman
Mar 9, 2012·Advances in Clinical Chemistry·Zhong-Chen WuLan Tan
Mar 29, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nicholas R EatonBrent W Roberts
Jun 28, 2012·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Benjamin ChapmanUNKNOWN Gingko Evaluation of Memory Study Investigators
Jul 17, 2012·Biological Psychiatry·Madhav ThambisettySusan M Resnick
Oct 9, 2012·International Journal of Geriatric Psychiatry·Ilan Dar-NimrodPaul R Duberstein
Oct 20, 2012·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ilan Dar-NimrodPaul R Duberstein
Aug 2, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David BunceSimon Easteal
May 29, 2014·Journal of the International Neuropsychological Society : JINS·Shannon K RungeRoger A Dixon
Jan 15, 2015·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Martina LuchettiAngelina R Sutin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Related Papers

International Journal of Geriatric Psychiatry
Ilan Dar-NimrodPaul R Duberstein
The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Martina LuchettiAngelina R Sutin
The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Ilan Dar-NimrodPaul R Duberstein
International Journal of Geriatric Psychiatry
Stephanie E WaggelHenry Brodaty
© 2021 Meta ULC. All rights reserved