Apolipoprotein E and lipoprotein lipase co-ordinately enhance binding and uptake of chylomicrons by human hepatocytes

European Journal of Clinical Investigation
W A MannU Beisiegel

Abstract

ApoE and LpL are important in the metabolism of triglyceride rich lipoproteins, and defects in either or both may result in hyperlipidaemia. It has previously been shown that ApoE and LPL specifically enhance cellular catabolism of lipoproteins by various cell lines. The authors determine in this paper the effect of ApoE and LpL on chylomicron and LDL binding and uptake by human hepatocytes in primary culture. Separate addition of ApoE and LpL greatly enhanced binding and uptake of chylomicrons. Simultaneous addition of ApoE and LPL further increased chylomicron uptake in an additive way. For LDL a different situation was observed: neither ApoE nor LPL mediated a significant increase of lipoprotein uptake. The authors conclude that ApoE and LpL co-ordinately enhance binding and uptake of chylomicrons by primary human hepatocytes. The effect appears to be independent of LDL receptors and the co-ordinate effect of ApoE and LPL may be important for normal chylomicron catabolism.

References

Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·U BeisiegelG Bengtsson-Olivecrona
May 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S P BabirakJ D Brunzell
Oct 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P R GalleH Schaller
Jun 1, 1994·European Journal of Biochemistry·A LookeneG Olivecrona
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F RinningerC E Broelsch
Jul 5, 1958·Nature·A S McFARLANE

❮ Previous
Next ❯

Citations

Mar 12, 2004·Brain Research. Developmental Brain Research·Eric ParadisM R Ven Murthy
Jul 1, 1997·The Proceedings of the Nutrition Society·U Beisiegel, J Heeren
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yiping DengJeffrey D Esko
May 4, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tomonaga IchikawaJianglin Fan
Mar 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Hong Wang, Robert H Eckel
Mar 31, 2012·Expert Review of Cardiovascular Therapy·Adie Viljoen, Anthony S Wierzbicki

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
U BeisiegelG Bengtsson-Olivecrona
Current Drug Targets
Adie Viljoen, A S Wierzbicki
© 2021 Meta ULC. All rights reserved