Apolipoprotein E epsilon 4 allele distribution in Wernicke-Korsakoff syndrome with or without global intellectual deficits

Journal of Neural Transmission
T MuramatsuH Kashima

Abstract

Recent genetic studies show that the apolipoprotein E (ApoE) epsilon 4 allele is a risk factor for Alzheimer's disease (AD). Whether this allele is associated with other dementing diseases is the next important question. The information could provide a clue to the pathogenetic role of ApoE. In the present study, patients with Wernicke-Korsakoff syndrome (WKS) of alcoholic etiology were divided into two groups according to the severity of intellectual deficits, i.e., those of "classical" Korsakoff patients with preserved intellectual function other than amnesia and those with global intellectual deficits. Genotyping showed that the frequency of ApoE epsilon 4 allele was significantly higher in the patients with global deficits, suggesting the involvement of this allele in the intellectual decline of WKS. In contrast, distributions of other two markers, alpha 1-antichymotrypsin and presenilin-1, did not differ between the two groups. These results added further support to the notion that the consequence of acute insult to the brain is influenced by the ApoE genotype, and suggested ApoE's role in the development of a certain group of "alcoholic dementia."

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
May 11, 1991·Lancet·P R WenhamG Blandell
May 1, 1990·Psychological Medicine·R R JacobsonW A Lishman
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M J IgnatiusE M Shooter
Aug 17, 1989·The New England Journal of Medicine·M E CharnessD A Greenberg
Apr 1, 1985·Journal of Clinical and Experimental Neuropsychology·N Butters
Aug 1, 1987·Psychological Medicine·R R Jacobson, W A Lishman
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J H Skene, E M Shooter
Sep 1, 1995·Nature Medicine·S SorbiL Amaducci
Jul 1, 1995·Annals of Neurology·J A SchneiderS S Mirra
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Jan 1, 1996·Journal of Neural Transmission·T MuramatsuS Higuchi

❮ Previous
Next ❯

Citations

Jun 15, 1999·Progress in Neurobiology·J J Kril, G M Halliday
Dec 20, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Irene GuerriniHugh M Gurling
Mar 5, 2005·European Neurology·Antonio Carota, Armin Schnider
Mar 5, 2005·European Neurology·Dirk M Hermann, Claudio L Bassetti
Nov 10, 2006·Annals of Human Biology·P P SinghS S Mastana
Apr 17, 2007·Lancet Neurology·Gianpietro Sechi, Alessandro Serra
Jun 28, 2005·Neurobiology of Aging·Seth LoveShelley J Allen
Jan 6, 2012·American Journal of Alzheimer's Disease and Other Dementias·Khanh vinh quoc Lu'o'ng, Lan Thi Hoang Nguyen
Sep 25, 2018·Frontiers in Psychiatry·Ching-Wen ChuNian-Sheng Tzeng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.