Apolipoprotein E epsilon4 allele frequency in vascular dementia

Dementia and Geriatric Cognitive Disorders
Yvonne DavidsonDavid M A Mann

Abstract

The aim of the study was to investigate whether possession of the epsilon4 allelic form of the apolipoprotein E (APOE) gene increases the risk of developing vascular dementia (VaD). APOE allele and genotype frequencies were determined by PCR in 89 patients with possible and probable VaD and compared with those in 97 patients with possible and probable Alzheimer's disease (AD) of similar age of disease onset and ethnic background, and with 766 control subjects drawn from the same geographical region. The APOE epsilon4 allele frequency in all 97 patients with possible and probable AD was significantly higher (p < 0.001) than that in control subjects. However, the APOE epsilon4 allele frequency in all 89 patients with possible and probable VaD was also significantly higher (p < 0.001) than that in control subjects, but not significantly different from that in AD. The APOE epsilon4 allele frequency was similarly, and still significantly (p < 0.001), increased when only those patients with probable AD or probable VaD were considered. Possession of APOE epsilon4 allele increases the risk of VaD.

References

May 11, 1991·Lancet·P R WenhamG Blandell
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·J KuusistoM Laakso
Apr 1, 1995·Neurology·L R Caplan
Nov 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·J KawamataJ Kimura
Sep 18, 1993·Lancet·S NoguchiN Yamada
Aug 1, 1996·Stroke; a Journal of Cerebral Circulation·H BasunM Viitanen
Oct 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·P W WilsonJ M Ordovas
Jan 1, 1996·Alzheimer Disease and Associated Disorders·T A TrevesA D Korczyn
Mar 12, 1997·JAMA : the Journal of the American Medical Association·A J SlooterR Mayeux
Jun 23, 1999·Acta Neuropathologica·H TomimotoH Budka
Nov 23, 2000·Journal of Neuropathology and Experimental Neurology·H V VintersH C Chui
Jul 10, 2001·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·C Loeb
May 2, 2002·Neuroscience Letters·Neil PendletonWilliam E R Ollier
Jan 22, 2003·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·R M RuggieriF Piccoli
Jul 24, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·S EngelborghsP P De Deyn
Jun 12, 2004·Current Atherosclerosis Reports·José A Luchsinger, Richard Mayeux
Jul 1, 2004·Annals of Human Genetics·M Ilyas Kamboh
Oct 13, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Ging-Yuek R HsiungHoward Feldman
Nov 13, 2004·Journal of the Neurological Sciences·Raj N KalariaTuomo Polvikoski

❮ Previous
Next ❯

Citations

Mar 13, 2012·Journal of Neurology·Lai QianYun Xu
Feb 3, 2009·Journal of Neural Transmission·H QureischieH Kölsch
Oct 11, 2011·Journal of Neural Transmission·Xu LiuZhiyi He
Dec 25, 2007·Journal of Molecular Neuroscience : MN·Anna KrasnianskiInga Zerr
Jun 3, 2009·Alzheimer Disease and Associated Disorders·James A MortimerWilliam R Markesbery
Apr 9, 2010·Dementia and Geriatric Cognitive Disorders·Yi-Fang ChuangPeter P Zandi
Aug 4, 2010·Neuroscience Letters·Bernadette McGuinnessAnthony Peter Passmore
Mar 22, 2012·Dementia and Geriatric Cognitive Disorders·Bo LiuYulan Tang
Sep 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Maria ParaskevaidiFrancis L Martin
Mar 22, 2007·Dementia and Geriatric Cognitive Disorders·Giuseppe OrsittoAlberto Pilotto
Apr 4, 2015·Journal of Alzheimer's Disease : JAD·Jia-Hao SunJin-Tai Yu
Feb 2, 2020·Molecular Neurodegeneration·Tosha WilliamsParamita Chakrabarty
Feb 13, 2020·International Journal of Molecular Sciences·Rita Moretti, Paola Caruso
Jan 4, 2008·The Journal of Infectious Diseases·Allison E AielloMary N Haan
Dec 11, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M BraininUNKNOWN Post Stroke Cognition Study Group
Sep 21, 2018·Nature Communications·Kenzo KoizumiCostantino Iadecola
Aug 2, 2019·Nature Reviews. Neurology·Yu YamazakiGuojun Bu
Jun 21, 2019·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Allison A DilliottRobert A Hegele
Aug 17, 2010·Journal of the Neurological Sciences·Dina ZekryKarl-Heinz Krause
Jun 6, 2018·ACS Chemical Neuroscience·Maria ParaskevaidiFrancis L Martin
Aug 24, 2021·Frontiers in Neuroscience·Ya-Ting HuangShu-Long Yang
Feb 26, 2011·Lancet Neurology·Philip B VergheseDavid M Holtzman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.