Apolipoprotein E gene and sporadic frontal lobe dementia

Neurology
M StevensJ van Swieten

Abstract

The apolipoprotein E gene has been associated with various types of dementia. We studied the connection between the APOE gene and the risk and onset of disease in 34 patients with clinically diagnosed frontal lobe dementia (FLD) derived from a population-based study in the Netherlands. A significant increased risk of FLD (odds ratio, 4.9; 95% CI, 1.1-20.1) was found for the apoE4E4 genotype when adjusting for age, sex, and family history of dementia other than FLD. The age at onset of the disease decreased as the number of APOE*4 alleles increased. Our population-based study suggests that persons who are homozygous for the APOE*4 allele are at increased risk for developing FLD.

Citations

Oct 31, 2002·Human Psychopharmacology·Kurt Heininger
Apr 26, 2012·Journal of Neurology·Chiara CeramiDaniela Galimberti
Dec 11, 2003·Neuroscience Letters·Enzo EmanueleDiego Geroldi
Mar 24, 2004·Neuroscience Letters·M BoccardiG B Frisoni
Jul 17, 1998·Journal of the Neurological Sciences· Walton
Feb 25, 2011·Alzheimer Disease and Associated Disorders·Emily Joy RogalskiMarek-Marsel Mesulam
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·R SrinivasanD M A Mann
Dec 16, 1998·Current Opinion in Neurology
May 19, 2007·Experimental Neurology·Stuart M Pickering-Brown
Dec 7, 2005·Mechanisms of Ageing and Development·Magnus Sjögren, Christian Andersen
May 22, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Elisa RubinoInnocenzo Rainero
Sep 6, 2014·Journal of Neurotrauma·Carrie Esopenko, Brian Levine
Jul 18, 2008·Handbook of Clinical Neurology·Stuart Pickering-Brown, Michael Hutton
Jan 7, 1999·Journal of Geriatric Psychiatry and Neurology·E Levy-LahadT D Bird
Jul 11, 2002·European Journal of Human Genetics : EJHG·Patrice VerpillatFrançoise Clerget-Darpoux
Dec 16, 1998·Current Opinion in Neurology·F Pasquier, A Delacourte
Jan 7, 1999·Journal of Geriatric Psychiatry and Neurology·K C Wilhelmsen
Jan 4, 2008·The Journal of Infectious Diseases·Allison E AielloMary N Haan
Feb 18, 2020·Journal of Alzheimer's Disease : JAD·Ting-Ting HouYi-Feng Du
Mar 21, 2019·BMC Medicine·Mirna SafiehDaniel M Michaelson
Dec 15, 2020·Translational Neuroscience·Pan WangYuying Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.