PMID: 15227722Jul 1, 2004Paper

Apolipoprotein E gene polymorphism and serum lipids in patients with superficial fungal disease

Yonsei Medical Journal
Umit TursenUgur Atik

Abstract

Superficial mycosis, including dermatophytic infections, tinea versicolor, and cutaneous candidiasis is mostly limited to the outer layers of the skin, nails, and mucous membranes. In this study, Apolipoprotein E (ApoE) polymorphism and lipoprotein cholesterol concentrations were compared between 42 patients with superficial fungal disease and 27 control subjects. Both the patients and controls were found to be normolipemic. The patients with superficial fungal disease had significantly higher concentrations of high-density cholesterol (HDL) compared to the control group (p=0.0462). However, there was no difference in the serum triglyceride, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol concentrations. A significantly higher incidence of heterozygosity E2/3 was found in the patients (p=0.0228), and significantly lower incidence of homozygosity E3/3 in all patients, and those with candidiasis and dermatophytosis (p=0.0139, 0.0194 and 0.0337, respectively) compared to the control group. The E3/4 genotype differences between patients and controls were not statistically significant. There were slight differences in the allele frequencies between the two groups, but these did not reach statistical...Continue Reading

Citations

Nov 26, 2010·Psychiatry and Clinical Neurosciences·Masatoshi TakedaRamón Cacabelos
Jul 23, 2014·PloS One·Caíque Silveira Martins da FonsecaVera Lúcia de Menezes Lima
May 6, 2019·Journal of Medical Microbiology·Sebastian GnatPrzemysław Zięba
Aug 10, 2016·Mycopathologia·Susan M Abdel-Rahman

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