Apolipoprotein E Gene Polymorphism and Subclinical Carotid Atherosclerosis: The Northern Manhattan Study

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Brett DolinerTatjana Rundek

Abstract

Apolipoprotein E (APOE) polymorphism has previously been associated with carotid intima-media thickness (cIMT) in predominantly Caucasian populations. We sought to test the strength of the relationship between APOE-ε4 carrier status and subclinical atherosclerosis in a tri-ethnic population with a large Hispanic representation. We assessed the association between APOE polymorphism and cIMT and plaque burden among 1243 stroke-free individuals (mean age 69 years, 65% Hispanic, 18% black, 17% white) using a sequence of multivariable regression models. After adjusting for demographics, vascular risk factors and plasma low-density lipoprotein (LDL) levels, APOE-ε4 carrier status was positively associated with cIMT (mean difference, .013 mm; 95% confidence interval, .003-.023 mm). The APOE-ε4 association with cIMT appeared to be segment-specific with greater differences in IMT between APOE-ε4 carriers and noncarriers in the common carotid artery (CCA, .014 mm) and bifurcation (.017 mm) than in the internal carotid artery (ICA) IMT (.007 mm). This relationship was not modified by race-ethnicity. Presence of diabetes modified the ε4-cIMT relationship in CCA (P = .045) and ICA (P = .046). APOE-ε4 carrier status was not associated with p...Continue Reading

References

Jul 1, 1984·Stroke; a Journal of Cerebral Circulation·G O RoedererD E Strandness
Mar 21, 1998·JAMA : the Journal of the American Medical Association·M X TangR Mayeux
Jan 19, 1999·JAMA : the Journal of the American Medical Association·R L SaccoM C Paik
Aug 4, 2001·Stroke; a Journal of Cerebral Circulation·R L SaccoS Shea
Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·A J SlooterC M van Duijn
Dec 12, 2001·The Journal of Biological Chemistry·Debi K SwertfegerDavid Y Hui
Mar 8, 2002·American Journal of Epidemiology·June E EichnerBerrit C Stroehla
Dec 25, 2003·Obesity Research·Roberto ElosuaJose M Ordovas
Jul 20, 2004·Journal of Lipid Research·Roberto ElosuaChristopher J O'Donnell
Dec 31, 2004·American Journal of Human Genetics·Hua TangNeil J Risch
Sep 20, 2005·Journal of the American College of Cardiology·Valentin FusterJuan J Badimon
Sep 22, 2005·American Journal of Human Genetics·UNKNOWN Race, Ethnicity, and Genetics Working Group
Jan 12, 2008·Clinical and Experimental Medicine·O OlivieriR Corrocher
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·J David Spence
Sep 13, 2008·Stroke; a Journal of Cerebral Circulation·Yi-Chu LiaoSuh-Hang Hank Juo
Dec 9, 2008·Journal of Lipid Research·Avani A PendseNobuyo Maeda
Dec 31, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·O UkkolaY A Kesäniemi
Aug 15, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Aloke V FinnRenu Virmani
May 3, 2012·Stroke; a Journal of Cerebral Circulation·Frank KuoTatjana Rundek
May 25, 2013·Stroke; a Journal of Cerebral Circulation·Tatjana RundekMoise Desvarieux
Dec 23, 2014·Free Radical Biology & Medicine·Francesca SantilliGiovanni Davì

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Citations

Jun 16, 2018·AIMS Neuroscience·Diana C OviedoGabrielle B Britton
Aug 17, 2020·The Journal of Pediatrics·Madeline A CzeckJustin R Ryder
May 11, 2021·Current Atherosclerosis Reports·A D Marais

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