Apolipoprotein E genotype in schizophrenia: frequency, age of onset, and neuropathologic features

Neuroreport
S E ArnoldR A Price

Abstract

Apolipoprotein E (ApoE) genotype has been found to affect the expression of a variety of neuropsychiatric disorders. We determined ApoE genotype frequencies and their relationship to clinical and pathological features in a diverse cohort of individuals with schizophrenia. There were no differences in ApoE genotype frequencies between schizophrenics and controls. However, the ApoE epsilon 4 genotype was associated with a younger age of onset of schizophrenia, and in an elderly subsample, individuals with the epsilon 4 allele more frequently exhibited co-existent dementia and had more neurofibrillary pathology (although none of the cases met criteria for Alzheimer's disease). This examination of ApoE in relation to clinical and neurobiological features of schizophrenia suggests that it modifies the phenotypic expression of the disease.

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Citations

Sep 18, 2003·Biological Psychiatry·Brian DeanRalph N Martins
Nov 26, 2010·Psychiatry and Clinical Neurosciences·Masatoshi TakedaRamón Cacabelos
Nov 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·R S WilsonD A Bennett
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Sep 16, 2015·Schizophrenia Research·Thelma Beatriz González-CastroMervyn Manuel Hernández-Alvarado
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May 8, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Daniel Martins-De-SouzaChristoph W Turck

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