Apolipoprotein E genotype modulates the effect of black tea drinking on blood lipids and blood coagulation factors: a pilot study

The British Journal of Nutrition
Alexandre LoktionovJ Cummings

Abstract

Apolipoprotein E (ApoE) genotype was determined in sixty-five subjects who had taken part in a 4-week randomized crossover trial to compare the effect of six mugs of black tea per day v. placebo on blood lipids and blood coagulation factors. Four ApoE genotype variants (seven E2/E3, forty-five E3/E3, twelve E3/E4 and one E4/E4) were found. ApoE allele frequency was within the range typical for Caucasian populations (ApoE-E2 5.4%; ApoE-E3 83.8%; ApoE-E4 10.8%). Individuals bearing at least one E4 allele had substantially higher levels of serum total cholesterol, LDL cholesterol and triacylglycerols. Mean plasminogen activator inhibitor (PAI-1) activity was higher in ApoE-E4 allele-bearing individuals (E3/E4 + E4/E4, 11.89 (SE 1.27) U/ml; E3/E3, 9.19 (SE 0.80) U/ml; E2/E3, 7.21 (SE 1.04) U/ml, P values of E4-group v. E3 and E2 being respectively 0.093 and 0.030). These unexpected findings imply that elevated PAI-1 activity may be a hitherto unrecognized additional factor involved in the increased cardiovascular disease risk associated with apoE-E4 allele. The interactions between tea drinking and genotype were also examined. In the E3/E3 homozygotes, HDL-cholesterol was significantly reduced in the tea period (mean placebo 1.54 m...Continue Reading

References

May 11, 1991·Lancet·P R WenhamG Blandell
Feb 1, 1991·Metabolism: Clinical and Experimental·M MänttäriV Manninen
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y K PaikJ M Taylor
Sep 4, 1987·JAMA : the Journal of the American Medical Association·W B KannelR B D'Agostino
Aug 31, 1985·British Medical Journal·J A ParamoF van de Werf
Apr 24, 1995·Atherosclerosis·W D ScheerJ P Middaugh
Jan 15, 1995·Circulation·M Dammerman, J L Breslow
Dec 7, 1994·JAMA : the Journal of the American Medical Association·P W WilsonE J Schaefer
Jan 1, 1994·Nature Genetics·F SchächterD Cohen
Jan 1, 1996·The American Journal of Clinical Nutrition·J A MarshallR E Ferrell
Oct 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·P W WilsonJ M Ordovas
Nov 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K H Weisgraber, R W Mahley
Jul 1, 1997·The British Journal of Nutrition·S A BinghamJ H Cummings

❮ Previous
Next ❯

Citations

Jul 13, 2001·The Journal of Nutritional Biochemistry·C J. Dufresne, E R. Farnworth
May 27, 1999·The Proceedings of the Nutrition Society·J M Ordovas
Nov 30, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·G SiestS Visvikis
Jul 21, 2011·Journal of Indian Society of Periodontology·Babu VenkateswaraVijay K Chava
Apr 7, 2000·Health Education Research·K ParmenterJ Wardle
Dec 10, 2003·Current Atherosclerosis Reports·David J Maron
Jan 4, 2015·Blood Reviews·Marlien Pieters, Moniek P M de Maat
Aug 9, 2005·Neuroscience Letters·Sherman C SteinDouglas H Smith
Sep 26, 2007·American Heart Journal·Kenneth J MukamalMurray A Mittleman
Jun 1, 2011·Annals of Medicine·Cesare R SirtoriReijo Laaksonen
Nov 10, 2006·Annals of Human Biology·P P SinghS S Mastana
Mar 30, 1999·Current Opinion in Lipidology·J M Ordovas, E J Schaefer
Apr 4, 2006·Journal of the American College of Nutrition·Carmen CabreraRafael Giménez
Mar 13, 1999·Current Opinion in Lipidology·S Samman
Aug 17, 2001·Current Opinion in Lipidology·B A Griffin
Feb 13, 2002·Journal of the American College of Nutrition·Diane L McKay, Jeffrey B Blumberg
Apr 16, 1998·The British Journal of Nutrition·C M Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.