Apolipoprotein-E genotypes and myasthenia gravis

Neurology India
Hamid SuhailMadhuri Behari

Abstract

Autoimmune myasthenia gravis (MG) is a disorder of neuromuscular junction. Possible role of multiple genes in the development of the MG has been documented. This case-control study, studied the association of apolipoprotein E (Apo-E) alleles with MG. Anti-AChR antibody was measured using radio receptor immunoassay. Apo-E genotypes were analyzed in 120 MG patients and 120 healthy subjects. Comparison between patients with MG and controls showed no significant association with Apo-E allelic variants. However, a significant association of Apo-E4 allele with AChR-antibody positive patients was observed (P = 0.007). Also, among seropositive patients, a significant association was seen between female gender and Apo-E4 allele (P = 0.023). Our results suggest that the presence of Apo-E4 allele might influence seropositive status in patients with MG and seems an associated susceptible factor in female patients.

References

May 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·A K LefvertR Pirskanen
Jan 13, 1987·Biochimica Et Biophysica Acta·R E PitasR W Mahley
Sep 1, 1994·Journal of Neuropathology and Experimental Neurology·S H HanD E Schmechel
Dec 1, 1995·Annals of Neurology·M J GarleppF L Mastaglia
Jan 1, 1997·International Journal of STD & AIDS·M Sadler, M Nelson
Jul 21, 1998·Annals of the New York Academy of Sciences·M SostarkoV Matić
Nov 14, 2000·Archives of Neurology·R S BedlackJ C Morgenlander
Nov 1, 2003·Annals of the New York Academy of Sciences·Angela VincentWerner Hoch

❮ Previous
Next ❯

Citations

Jun 4, 2016·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Hannan Al-RayesAbdulrahman Al-Asmari
Feb 7, 2021·Archives of Biochemistry and Biophysics·Mariela L Paz, Francisco J Barrantes

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.