Apolipoprotein E genotypes in offspring with a positive and negative family history of premature myocardial infarction

Clinical Genetics
K RaslováM Dusinská

Abstract

Apolipoprotein E (apo-E) allele and genotype frequencies were evaluated in offspring with positive (MI-offspring) and negative (control-offspring) parental history of myocardial infarction (MI). The apo-E allele frequencies in MI- and control-offspring were as follows: epsilon2: 9.04 and 2.08% (p < 0.02), epsilon3: 84.04 and 87.5%, epsilon4: 6.91 and 10.41%, respectively. The frequencies of the E2-genotypes were significantly lower in offspring of controls (4.2%, 17.0%, respectively, p < 0.03). The epsilon2-allele is associated with raised plasma triglyceride concentrations in subjects on a diet high in saturated fat. We therefore hypothesize that offspring carrying an epsilon2-allele are predisposed to develop disturbance of plasma triglyceride metabolism when exposed to a traditional Slovak high-fat diet and/or weight gain, resulting in altered lipid levels and increased predisposition to atherosclerosis.

References

Oct 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·B C MortimerE M Rubin
Sep 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·G LucF Cambien

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Citations

Mar 29, 2001·Anesthesia and Analgesia·M F NewmanA M Saunders
Apr 28, 2005·International Journal of Clinical Practice·P PudduA Muscari
Apr 20, 2001·Clinical Biochemistry·J A HubacekP J Talmud

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