PMID: 9447448Jan 1, 1997Paper

Apolipoprotein E genotyping as a diagnostic adjunct for Alzheimer's disease

International Psychogeriatrics
A D Roses, A M Saunders

Abstract

Positive predictive value (PPV) estimates how often a particular test predicts the eventual diagnosis, and it is the basis of any test that attempts to establish a diagnosis. Calculating the PPV depends directly on the entrance criteria for considering the diagnosis and the exit criteria of the generally accepted "gold standard" for establishing the ultimate diagnosis. For a relatively common disease such as AD, the practical usefulness of a diagnostic test also relates to the stage of the disease at which the test can be applied. An accurate and predictive test only has practical value when it can be used early in the course of the disease. Apolipoprotein E (Apo E) is the first genetic locus identified as a susceptibility polymorphism for a common complex disease using positional or candidate cloning strategies. There are three common alleles (epsilon 2 to epsilon 4) and six possible genotypes; about 30% of the population carries an epsilon 4 allele, each additional copy of which is associated with an increased risk of AD and earlier age of onset distribution. In patients with cognitive impairment of the Alzheimer type, who have been diagnosed with possible or probable AD, the presence of an Apo E-epsilon 4 allele is likely in...Continue Reading

Citations

Sep 6, 2008·Molecular Neurobiology·Daniela L RebolledoNibaldo C Inestrosa
May 28, 2003·Journal of the Neurological Sciences·Osamah ElwanNervana El Faiuomy
Oct 20, 2001·Behavioural Brain Research·L Fernández-Novoa, R Cacabelos
Aug 29, 2002·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Karen HookerFuzhong Li
Sep 28, 2002·The Gerontologist·Richard SchulzAlan Stevens
Nov 5, 2005·Journal of Advanced Nursing·Eun-Hi Kong
Feb 25, 1999·International Journal of Geriatric Psychiatry·R CacabelosB Winblad
Aug 13, 2002·The Medical Clinics of North America·Debby W Tsuang, Thomas D Bird

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