Apolipoprotein E in Cardiovascular Diseases: Novel Aspects of an Old-fashioned Enigma

Archives of Medical Research
Elisa A LiehnHector A Cabrera-Fuentes

Abstract

The presence of different APOE isoforms represents a well-known risk factor for cardiovascular diseases. Besides the pleiotropic effects of APOE polymorphism on heart and neurological diseases, this review summarizes the less-known functions of APOE and the possible implications for cardiovascular disorders. Beyond the role as lipid transporting protein, its involvement in lipid membrane homeostasis and signaling, as well as its nuclear transcriptional effects suggests a more complex role of APOE, receiving great interest from researchers and physicians from all medical fields. Due to the presence of different APOE isoforms in human population, understanding APOE's role in pathological processes represents not only a challenge, but a demand for further development of therapeutic strategies for cardiovascular diseases.

Citations

May 22, 2019·International Journal of Molecular Sciences·Jonathan YapWilliam A Boisvert
Jan 27, 2019·Scientific Reports·Juho-Pekka KarjalainenTerho Lehtimäki
Sep 27, 2019·Pharmacological Reviews·Dongdong WangAtanas G Atanasov
Mar 21, 2019·BMC Medicine·Mirna SafiehDaniel M Michaelson
Mar 18, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sandra Van der AuweraHans J Grabe
Apr 7, 2021·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Teresa Arrobas VelillaUNKNOWN en representación del Grupo de trabajo pilotaje proyecto ARIAN-Andalucía

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Related Papers

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Zhi-jie XiaoJun Wu
Trends in Biochemical Sciences
Danny M HattersK H Weisgraber
The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Amanda J Myers, Charles B Nemeroff
Current Opinion in Lipidology
K H WeisgraberW J Strittmatter
© 2022 Meta ULC. All rights reserved