PMID: 8584252Oct 20, 1995Paper

Apolipoprotein E in sporadic and familial Creutzfeldt-Jakob disease

Neuroscience Letters
M SalvatoreM Pocchiari

Abstract

We assessed the apolipoprotein E (ApoE) genotype in 49 sporadic and ten familial Creutzfeldt-Jakob disease (CJD) patients, in seven healthy siblings with a PRNP mutation and in 84 controls. In sporadic CJD, ApoE genotypes and allelic frequencies do not significantly differ from that of controls. No influence of ApoE genotypes on age at onset was found. In familial cases, the disease appeared in mutated subjects showing the same ApoE genotype as members who have not yet developed CJD. Our results provide further evidence that ApoE is not a risk factor for CJD.

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Citations

May 7, 2009·Journal of Neurology·Inês Esteves BaldeirasCatarina Resende Oliveira
Jun 12, 1998·Brain Research. Brain Research Reviews·U BeffertJ Poirier
Jul 26, 2008·Archives of Gerontology and Geriatrics·G AnnoniC Vergani
Jan 17, 1997·Neuroscience Letters·N J CairnsP L Lantos
Apr 17, 2001·Neuropathology : Official Journal of the Japanese Society of Neuropathology·R A ArmstrongP L Lantos
Jan 26, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A PoleggiC Masullo
Dec 18, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yunfei WeiChao Qin
Dec 25, 2007·Journal of Molecular Neuroscience : MN·Anna KrasnianskiInga Zerr
Sep 8, 2007·Neurobiology of Aging·Anna KrasnianskiInga Zerr
Oct 10, 2006·Bioscience Reports·Fabio CoppedèLuigi Murri
Dec 18, 2020·Frontiers in Neurology·Eva ParobkovaRadoslav Matej
Feb 26, 2011·Lancet Neurology·Philip B VergheseDavid M Holtzman

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