Abstract
Lifestyle changes in Alaskan Natives have been related to the increase of cardiovascular disease and metabolic syndrome in the last decades. Variation of the apolipoprotein E (Apo E) genotype may contribute to the diverse response to diet in lipid metabolism and influence the association between fatty acids in plasma and risk factors for cardiovascular disease. The aim of this investigation was to analyze the interaction between Apo E isoforms and plasma fatty acids, influencing phenotypes related to metabolic diseases in Alaskan Natives. A sample of 427 adult Siberian Yupik Alaskan Natives was included. Fasting glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, Apo A1, and Apo B plasma concentrations were measured using reference methods. Concentrations of 13 fatty acids in fasting plasma were analyzed by gas chromatography, and Apo E variants were identified. Analyses of covariance were conducted to identify Apo E isoform and fatty acid main effects and multiplicative interactions. The means for body mass index and age were 26 ± 5.2 and 47 ± 1.5, respectively. Significant main effects were observed for variation in Apo E and different fatty acids influencing A...Continue Reading
References
Mar 1, 1990·American Journal of Public Health·J P Middaugh
Apr 24, 1995·Atherosclerosis·W D ScheerJ P Middaugh
Sep 7, 1999·European Journal of Clinical Nutrition·J T SnookN Lee
Sep 14, 2000·American Journal of Human Genetics·S M FullertonC F Sing
Aug 31, 2001·European Journal of Clinical Nutrition·L E BautistaC Serrano
Mar 8, 2002·American Journal of Epidemiology·June E EichnerBerrit C Stroehla
Feb 18, 2004·International Journal of Circumpolar Health·Catherine SchumacherGretchen Ehrsam
Jun 18, 2005·The Proceedings of the Nutrition Society·Andrew M PrenticeSophie E Moore
Jun 29, 2005·Journal of the American Dietetic Association·Margaret A Allman-FarinelliPeter Petocz
Nov 10, 2005·International Journal of Circumpolar Health·Sven O E EbbessonDavid C Robbins
Feb 16, 2006·Lipids·Penny M Kris-EthertonTerry D Etherton
Feb 16, 2006·Lipids·Ronald P Mensink
May 1, 2007·The Proceedings of the Nutrition Society·A M MinihaneG Rimbach
Sep 20, 2007·JAMA : the Journal of the American Medical Association·Anna M BennetJohn Danesh
Dec 12, 2007·Genetika·S A BorinskaiaN K Iankovskiĭ
Nov 26, 2008·The British Journal of Nutrition·Juan Antonio MorenoJosé López-Miranda
Feb 28, 2009·The Proceedings of the Nutrition Society·Gerald Rimbach, Anne M Minihane
Aug 14, 2009·The British Journal of Nutrition·Thaddeus H AdamsStephen B Smith
Sep 22, 2009·Metabolism: Clinical and Experimental·Juan C Lopez-AlvarengaAnthony G Comuzzie
Apr 22, 2010·BMC Medical Genetics·Man-huei ChangNicole F Dowling
Aug 20, 2010·International Journal of Circumpolar Health·Sven O E EbbessonAnthony G Comuzzie
Aug 2, 2011·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Eva TvrzickaAles Zak
Nov 9, 2012·The American Journal of Clinical Nutrition·Andrew L Carvalho-WellsAnne M Minihane
Mar 8, 2013·Atherosclerosis·Shuang LiangMichael Y Tsai
Mar 7, 2014·Journal of Cardiovascular Translational Research·William S HarrisJoseph P McConnell
Oct 22, 2014·The Journal of Nutrition·M Virtu Calabuig-NavarroJulie A Lovegrove
Nov 11, 2014·Molecular Nutrition & Food Research·Patricia HuebbeGerald Rimbach
Citations
Dec 21, 2018·Stroke; a Journal of Cerebral Circulation·Claudia L SatizabalSudha Seshadri
Aug 1, 2020·Scientific Reports·Małgorzata SzczukoArleta Drozd
Oct 20, 2018·Nutrients·Bruce A GriffinJulie A Lovegrove
Dec 5, 2020·Pharmacogenomics and Personalized Medicine·Rafael Torres-ValadezEloy A Zepeda-Carrillo