PMID: 11907943Mar 23, 2002Paper

Apolipoprotein E phenotype associations with plasma lipoproteins and bone mass in postmenopausal women

Climacteric : the Journal of the International Menopause Society
M SanadaK Ohama

Abstract

The aim of the study was to investigate the effects of apolipoprotein E (apo E) phenotype on plasma lipids and bone mass in postmenopausal Japanese women. In 320 subjects aged 40-65 years (mean +/- SE, 54.0 +/- 0.6), apo E phenotype was determined by isometric electrophoresis. Phenotypic frequencies were 0.3% for E2/2 (n = 1), 8.1% for E3/2 (n = 26), 70.3% for E3/3 (n = 225), 0.6% for E4/2 (n = 2), 19.4% for E4/3 (n = 62) and 1.3% for E4/4 (n = 4). Apo E2/2 and apo E3/2 were classified as E2+ (n = 27); apo E3 homozygotes were placed in another group (E3/3; n = 225), as were apo E4/3 together with apo E4/4 subjects (group E4+; n = 66). Bone density and bone quality were assessed with a newly developed ultrasonic bone densitometer, and plasma lipids were also measured. Age, body mass index and years since menopause did not differ significantly between the three groups. The E4+ group had the highest levels of total cholesterol, low-density lipoprotein cholesterol and apolipoprotein B, significantly higher than in the E2+ group. Plasma lipoprotein(a) concentrations were significantly higher in the E4+ group than in the other two groups. Ultrasonic parameters of bone density and quality tended to be lower in the E4+ group than in th...Continue Reading

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Citations

May 1, 2007·The Proceedings of the Nutrition Society·A M MinihaneG Rimbach
Mar 17, 2004·The Proceedings of the Nutrition Society·Siobhán Cusack, Kevin D Cashman
Jul 30, 2011·Bone·Andreas NiemeierMichael Amling

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