PMID: 9448441Feb 4, 1998Paper

Apolipoprotein E phenotype is not related to late-life depression in a population-based sample

Social Psychiatry and Psychiatric Epidemiology
B SchmandL M Havekes

Abstract

Apolipoprotein E (ApoE) allele frequencies were examined in a population-based sample (n = 475: age range 65-84 years: Amsterdam Study of the Elderly). The relation of ApoE epsilon 4 with dementia and with various types of late-life depression was studied. Depression was measured with the Geriatric Mental State schedule. Dementia was diagnosed by DSM-III-R criteria. It was expected that ApoE epsilon 4 allele frequencies would be elevated not only in Alzheimer's disease and dementia in general, but also in first episode, late-life depression accompanied by subtle cognitive impairment (possibly organic depression). However, the results indicated that epsilon 4 allele frequency is related to (family history of) dementia and cognitive impairment, but not to possibly organic depression. The main predictor of late-life depression is an episode of psychiatric problems before the age of 65 years.

Citations

Oct 17, 2007·Molecular Psychiatry·S López-LeónC M van Duijn
Mar 21, 2002·Biological Psychiatry·Do Hoon KimDavid C Steffens
Feb 1, 2017·Neuroscience and Biobehavioral Reviews·Ruby S M TsangSimone Reppermund
Jul 27, 2000·Journal of Geriatric Psychiatry and Neurology·D G HarwoodR Duara
May 24, 2000·International Journal of Geriatric Psychiatry·R Rao
Oct 31, 2002·International Journal of Geriatric Psychiatry·Isaac SchweitzerDavid Ames
Sep 7, 2006·Dementia and Geriatric Cognitive Disorders·Jen-Ping HwangShih-Jen Tsai
Mar 8, 2007·Neurochemical Research·Gemma CasadesusGeorge Perry
Feb 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·N TunstallS Lovestone

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