PMID: 9429989Jan 16, 1998Paper

Apolipoprotein E phenotypes and cardiovascular responses to experimentally induced mental stress in adolescent boys

Journal of Behavioral Medicine
N RavajaL Keltikangas-Järvinen

Abstract

We investigated the relationship between apolipoprotein E (apoE) polymorphism and cardiovascular responses to experimentally induced mental stress. Mental stress was induced in 28 healthy 16-year-old boys with a series of stressors (e.g., mental arithmetic, Stroop Color-Word Interference Test). Heart rate (HR), finger blood volume, and skin conductance level were recorded continuously during the task performance. We found that boys with apoE3/2 or apoE3/3 showed marginally significantly greater HR reactivity and significantly greater task levels of HR and HR variability (HRV) during the mental stress than subjects with apoE4/2, apoE4/3, or apoE4/4. In addition, E4/2, E4/3, and E4/4 subjects manifested a distinct stress-related decrease in HRV relative to baseline values while E3/2 and E3/3 subjects showed a slight increase. The results suggests that apoE polymorphism is associated with cardiovascular responsivity to mental stress in adolescent boys.

Citations

Dec 6, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Daniel J Glass, Steven E Arnold
Jan 1, 1999·Annals of Medicine·Hans K ÅkerblomMatti Uhari
Mar 1, 2019·Journal of Alzheimer's Disease : JAD·Carr J SmithThomas A Perfetti
Nov 2, 2006·Cerebral Cortex·Christian R A MondadoriKatharina Henke
Feb 6, 2021·Journal of Clinical Medicine·Colt A CoffmanRobert Davis Moore
Dec 22, 1999·Neurobiology of Aging·C E Finch, R M Sapolsky

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