Apolipoprotein E polymorphism and fertility: a study in pre-industrial populations

Molecular Human Reproduction
R M CorboG F De Stefano

Abstract

Human apolipoprotein E is the most important supplier of the cholesterol precursor for steroid hormone production in steroidogenic tissues and therefore could play a role in the regulation of steroid hormone function and influence human reproduction. This hypothesis has been confirmed by studies describing a differential fertility associated with common apolipoprotein (APOE) genotypes in two European populations. In the present investigation the impact of APOE genetic variation on fertility was studied in two Ecuadorian populations, African-Ecuadorians (57 women) and Cayapa Indians (27 women). In addition some biodemographic variables concerning women's fertility were investigated (124 African-Ecuadorian women; 40 Cayapa women) to better understand the APOE-fertility relationships in these pre-industrial populations. General fertility rates in both populations were very high (6.5 and 6.2 for the African-Ecuadorians and for the Cayapa respectively). When considering only women near the end of reproductive life (>/=40 years), a more marked difference was observed between the two groups (9.1 versus 7.7, P=0.09). In both communities, the highest number of children was found to be associated with the e*4/e*3 genotype; the e*4/e*3 ge...Continue Reading

Citations

Feb 28, 2007·Current Infectious Disease Reports·Richard L GuerrantAldo A M Lima
Jun 18, 2005·The Proceedings of the Nutrition Society·Andrew M PrenticeSophie E Moore
Jan 24, 2012·Molecular Human Reproduction·Madeline S CollazoSummer F Acevedo
Apr 3, 2009·The American Journal of Clinical Nutrition·José M Ordovas
Feb 19, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·M B JacobsW Chen
May 10, 2012·Systems Biology in Reproductive Medicine·Rohollah SetarehbadiHeidar Tavilani
Mar 10, 2016·Fertility and Sterility·Silvia Gamundi-SeguraJose M Arbones-Mainar
Feb 10, 2006·International Journal of Andrology·Hans-Peter KohlerKaare Christensen
Jul 7, 2017·PloS One·Eric van ExelRudi G J Westendorp
Oct 21, 2017·Evolution; International Journal of Organic Evolution·Jean-Michel Gaillard, Jean-François Lemaître
Jul 26, 2018·International Journal of Molecular Sciences·Sarah DallelSalwan Maqdasy
Mar 1, 2019·Journal of Alzheimer's Disease : JAD·Carr J SmithThomas A Perfetti
Jun 11, 2011·Critical Reviews in Clinical Laboratory Sciences·Khemanganee E LiyanageFrank M van Bockxmeer
Apr 12, 2012·International Journal of Andrology·D PaoliL Gandini
Dec 22, 2019·Journal of Molecular Evolution·Sean G Byars, Konstantinos Voskarides
Aug 15, 2014·Biology of Reproduction·Anthony M DeAngelisAnnabelle Rodriguez
Feb 23, 2020·Neurobiology of Disease·Ana B Martínez-MartínezJose M Arbones-Mainar
Jul 21, 2020·Trends in Endocrinology and Metabolism : TEM·Reinaldo Barreto OriáJosé Ricardo Figueiredo

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.