Apolipoprotein E polymorphism and lipoprotein compositions in normolipidaemic xanthelasma patients

Journal of the European Academy of Dermatology and Venereology : JEADV
U TursenU Atik

Abstract

Apolipoprotein E (apoE) phenotypes and lipoprotein compositions in xanthelasma patients have been reported in different series. To investigate the apoE polymorphism and lipoprotein compositions in xanthelasma patients by using rapid polymerase chain reaction, and searched for an association between apoE polymorphism and the lipoprotein levels in xanthelasma patients. ApoE polymorphism and the different types of serum lipoproteins were studied in 25 patients with xanthelasma and compared with 27 normal subjects. All of patients were found to be normolipidaemic. The patients had significantly higher concentrations of total cholesterol and apolipoprotein B, and lower concentrations of apolipoprotein A. There was no difference in serum triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol concentrations. The distribution of apoE genotypes and alleles was the same in both groups. The apoB, apoA and cholesterol levels did show statistically significant differences in the direction of an increased risk of atherosclerosis. Patients with xanthelasma demonstrated slight differentiations in the apoE polymorphism and metabolism of lipoproteins that require further clarifications.

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Citations

Jan 18, 2008·International Journal of Clinical Practice·M Crook
Sep 17, 2011·BMJ : British Medical Journal·Mette ChristoffersenAnne Tybjærg-Hansen
Nov 22, 2015·Ageing Research Reviews·Mette Christoffersen, Anne Tybjærg-Hansen
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May 21, 2021·Journal of Inflammation Research·Hsuan-Wei ChenYi-Lin Chiu

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