Apolipoprotein E polymorphism and stroke in a population from eastern Turkey

Journal of Neurogenetics
Selma DuzenliOrhan Deniz

Abstract

Human apolipoprotein E (apo E) alleles are polymorphic with significantly different frequencies among different ethnic groups and have been associated with increased risk of coronary heart disease, and postulated as a major genetic susceptibility locus for Alzheimer's disease. Studies undertaken in different populations have shown different association patterns between apo E genotype and stroke. The aim of this study was to determine the risk of apo E genotype in stroke patients living in the eastern part of Turkey. The apo E genotypes and allele frequencies of 229 individuals from the same geographic area were determined by polymerase chain reaction and restriction fragment length polymorphism, of which 103 were patients with a documented history of stroke without other apparent dementia and 126 age-matched healthy subjects as a control group. A reduced E3/4 genotype frequency was found in subjects with stroke and the E2/3 genotype frequency was elevated in patients with previous stroke. There was no association between apo E epsilon4 allele and stroke. The APOE alleles had divergent effects in this population. Association between APOE (the gene) alleles and stroke in this population may be altered due to interaction with othe...Continue Reading

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Citations

Aug 9, 2011·Genetic Testing and Molecular Biomarkers·Rongjun ZhangWei Shao
Jun 26, 2008·The International Journal of Neuroscience·Nebahat TasdemirM Serhan Tasdemir
May 26, 2009·The International Journal of Neuroscience·Yusuf TamamKenan Iltumur
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Jul 2, 2010·Critical Reviews in Clinical Laboratory Sciences·Sanja Stankovic, Nada Majkic-Singh

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