Apolipoprotein E polymorphism and gallstones

Gastroenterology
A BertomeuJ M Ribó

Abstract

Apolipoprotein (apo) E is a genetically polymorphic protein influencing lipoprotein metabolism and the risk of both atherosclerosis and Alzheimer's disease. As opposed to common apo E3, apo E2 decreases and apo E4 increases hepatic lipoprotein uptake; hence, apo E4 could promote gallstone formation by increasing hepatic and biliary cholesterol concentrations. This study was designed to evaluate whether apo E polymorphism is related to gallstone risk. apo E phenotype was determined in subjects older than 40 years of age (160 with and 125 without gallstones) and in 61 patients with cholesterol gallstones who underwent cholecystectomy. Bile composition, nucleation time, and gallstone features were analyzed in surgical patients. The E4/3 phenotype was enriched in both patients with gallstones and those who underwent cholecystectomy, with significantly (P < 0.006) higher epsilon 4 allele frequencies than in gallstone-free subjects (odds ratio, 2.67 [95% confidence limits, 1.23-5.93] and 3.62 [95% confidence limits, 1.49-8.91], respectively); women, but not men, accounted for these differences. The prevalence of the epsilon 4 allele increased with age in patients with gallstones, whereas the opposite occurred in gallstone-free subjec...Continue Reading

Citations

Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K J Van ErpecumA K Groen
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R JalanJ M Wardlaw
Jun 12, 2004·Current Gastroenterology Reports·David Q-H Wang, Nezam H Afdhal
Oct 29, 1998·Mechanisms of Ageing and Development·Z Jian-GangH Lin
Jun 25, 2003·Journal of Hepatology·Karel J van ErpecumDieter Jüngst
Oct 22, 2003·Archives of Medical Research·Segundo MoránMisael Uribe
Apr 13, 1999·Gastroenterology Clinics of North America·J M Donovan
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Frank Lammert, Tilman Sauerbruch
May 4, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Beth A Carter, Robert J Shulman
Sep 3, 2004·Nature Reviews. Cancer·Ignacio I Wistuba, Adi F Gazdar
Oct 9, 2001·European Journal of Clinical Investigation·S FischerD Jüngst
Oct 26, 1999·Journal of Gastroenterology and Hepatology·M TraunerR E Stauber
Jun 11, 2003·Journal of Gastroenterology and Hepatology·Makoto HojoHajime Takikawa
Feb 26, 2000·Pathology International·M PirisiC A Beltrami
May 29, 2002·Pathology International·Tatsuhiko SuzukiTooru Shimosegawa
Nov 7, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·V D'OnofrioG Iaquinto
Oct 13, 2006·Current Opinion in Gastroenterology·S P Lee, C W Ko
May 29, 2004·Current Opinion in Lipidology·Silvana ZanlungoFlavio Nervi
Aug 18, 2005·Journal of Gastroenterology and Hepatology·Te-Sheng ChangYun-Fan Liaw
Oct 8, 2009·Cancer Research·Lee E MooreNathaniel Rothman
Feb 26, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gabriella AndreottiAnn W Hsing
Aug 14, 1998·Pediatric Research·M ArreseF J Suchy
Jun 9, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Eun-Hyung Yoo, Soo-Youn Lee
Jul 19, 2003·Psychiatry·Erik J A ScherderJoseph A Sergeant
Sep 28, 2010·World Journal of Gastroenterology : WJG·Jaime Sánchez-CuénRosalío Ramos-Payán
May 19, 2010·Gastroenterology Clinics of North America·Laura M StintonEldon A Shaffer
May 19, 2010·Gastroenterology Clinics of North America·Helen H WangDavid Q H Wang
Mar 10, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Silvana Zanlungo, Attilio Rigotti
Oct 27, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Anshika SrivastavaBalraj Mittal
Jan 10, 2006·American Journal of Human Genetics·Sobha PuppalaRavindranath Duggirala
May 9, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian D Juran, Konstantinos N Lazaridis
Mar 9, 2007·Orvosi hetilap·Krisztina Hagymási, Zsolt Tulassay
Jan 16, 2003·Biochimica Et Biophysica Acta·Astrid KostersAlbert K Groen

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