Apolipoprotein E polymorphism is associated with age of onset in schizophrenia

Journal of Human Genetics
Olli KampmanTerho Lehtimäki

Abstract

The aims of the study were to investigate the relationship between Apolipoprotein E (APOE) polymorphism, risk of schizophrenia, treatment response to conventional anti-psychotics, and age of onset in schizophrenia. The sample comprised 94 Finnish patients with a DSM-IV diagnosis of schizophrenia. Forty-three of the patients were good responders to conventional anti-psychotics and 51 were classified as non-responders. The control group consisted of 98 healthy blood donors. The APOE allele frequencies (epsilon 2, epsilon 3, and epsilon 4) were 4.8, 72.3, and 22.9% in patients and 7.1, 75.0, and 17.9 in controls. None of the differences between groups were statistically significant. No association between treatment response and APOE genotype was found. Patients with APOE epsilon 4/epsilon 4 genotype had a markedly lower age of onset compared with rest of the sample (p=0.0015), which remained significant when controlling for gender (p=0.02). There was an increasing linear trend between the number of epsilon 3 alleles (0, 1, or 2) and age of onset in schizophrenia (p=0.08). An inverse trend was found between the number of epsilon 4 alleles and age of onset (p=0.07). No relationship between APOE polymorphism and risk for schizophreni...Continue Reading

References

Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·E JönssonG Sedvall
Apr 15, 1997·Biological Psychiatry·R Igata-YiT Miyakawa
Aug 1, 1997·Neuroscience Letters·T KimuraT Miyakawa
Mar 20, 1999·Genetic Analysis : Biomolecular Engineering·K J Livak
Sep 20, 2000·Psychiatric Genetics·N DuranyF F Cruz-Sánchez
Apr 3, 2001·The Journal of ECT·M FismanJ Appell
Nov 10, 2001·Annual Review of Genomics and Human Genetics·R W Mahley, S C Rall
Jun 28, 2002·Acta Psychiatrica Scandinavica·P A SáizJ Bobes
Oct 24, 2002·Social Psychiatry and Psychiatric Epidemiology·Ch DalmanP Allebeck
Nov 14, 2002·Molecular Neurobiology·J Gregor Sutcliffe, Elizabeth A Thomas
Jan 11, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Werner KochAdnan Kastrati
Apr 23, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Franck SchürhoffMarion Leboyer
Jun 19, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Lars Ulrik Gerdes
Sep 18, 2003·Biological Psychiatry·Brian DeanRalph N Martins
Sep 27, 2003·Biological Psychiatry·Greer M MurphyUNKNOWN Mitrazapine versus paroxetine Study Group

❮ Previous
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Citations

Nov 26, 2009·Molecular Psychiatry·S M KurianA B Niculescu
Nov 26, 2010·Psychiatry and Clinical Neurosciences·Masatoshi TakedaRamón Cacabelos
Jan 25, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Sebastian KöhlerUNKNOWN Medical Research Council Cognitive Function and Ageing Study
Jun 23, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·D ClarkM J Arranz
Jun 20, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S NadalinA Buretić-Tomljanović
Sep 16, 2015·Schizophrenia Research·Thelma Beatriz González-CastroMervyn Manuel Hernández-Alvarado
Jun 21, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ke-Sheng WangYue Pan
Apr 8, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Elizabeth HareMichael A Escamilla
Mar 29, 2006·Schizophrenia Research·Ming-Qing XuLin He
Jan 28, 2015·World Journal of Gastroenterology : WJG·Ebtissam Saleh Al-MeghaiseebAbdulrahman K Al-Asmari
Jun 7, 2011·Molecular Biology Reports·Alena Buretić-TomljanovićSmiljana Ristić
Jun 30, 2010·The International Journal of Neuroscience·Miljana KecmanovićStanka Romac

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