Apolipoprotein E polymorphism modulation of asymmetric dimethylarginine in hypertensive patients is determined by renal function

Lipids in Health and Disease
Mauro Sergio Martins MarrocosMarcelo Costa Batista

Abstract

Endothelial dysfunction is considered an early step of atherosclerotic vascular disease. Asymmetric dimethylarginine (ADMA), the main endogenous inhibitor of nitric oxide synthase (NOS), plays a critical role in the process of atherosclerosis in a uremic environment. Increased plasma ADMA not only works as a cardiovascular morbidity biomarker but it is also involved in the genesis of atherosclerosis in renal disease. Considering the relationships of apolipoprotein E(ApoE) polymorphism with LDL cholesterol (LDL-C) levels and coronary risk, it is possible that it brings on susceptibility to endothelial dysfunction and atherogenesis seen on uremia. Six hundred twenty patients were stratified according to glomerular filtration rate (GFR) estimated by Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) formula: group I > 60 mL/min, group II ≤ 60 mL/min and > 15 mL/min, and group III ≤ 15 mL/min or in hemodialysis. Polymorphic ApoE analysis was performed by polymerase chain reaction amplification (PCR). Plasma ADMA levels were measured by high performance liquid chromatography (HPLC). Groups were compared on clinical and laboratory characteristics as well as allele and genotype distribution towards. The ε2 allele of ApoE was p...Continue Reading

References

Sep 9, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·J P Cooke
Aug 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J T KielsteinD Fliser
Dec 6, 2002·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliPietro Finocchiaro
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Evagelos LiberopoulosMoses Elisaf
Mar 10, 2005·Human Biology·Aida X Medina-UrrutiaCarlos Posadas-Romero
Apr 22, 2005·Scandinavian Journal of Urology and Nephrology·Louis RoussosClaes-Henrik Floren
Jun 3, 2005·Journal of the American Society of Nephrology : JASN·Danilo FliserEberhard Ritz
Jun 30, 2006·Journal of the American Society of Nephrology : JASN·Kyoko MatsugumaSeiya Okuda
Jul 1, 2006·Stroke; a Journal of Cerebral Circulation·Jan T KielsteinStefanie M Bode-Böger
Sep 5, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Haruhito Adam UchidaHirofumi Makino
Sep 20, 2007·JAMA : the Journal of the American Medical Association·Anna M BennetJohn Danesh
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jul 1, 2009·Biochemical Genetics·Jaroslav A HubacekMartin Bobak
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Mar 30, 2011·Nature Reviews. Nephrology·Edzard Schwedhelm, Rainer H Böger
Jun 7, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Tse-Min LuShing-Jong Lin
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jun 27, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rajiv SaranKevin C Abbott

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Methods Mentioned

BETA
PCR
electrophoresis

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