Apolipoprotein E: possible therapeutic target for atherosclerosis

Current Drug Targets. Cardiovascular & Haematological Disorders
L BockschB Singh

Abstract

Human apolipoprotein E (apoE) consists of a single polypeptide chain with 299 amino acids and is best known for its role in the transport of cholesterol and other lipids between peripheral tissues and the liver. However, more direct effects of apoE on the vascular wall may well contribute to arterial protection from atherosclerosis. This review will focus on: (a) the ability of apoE to direct cholesterol efflux mechanisms with the aid of apoA1 and the ATP binding cassette transporter 1 (ABC1); (b) the ability of apoE to prevent platelet aggregation by facilitating the production of endogenous nitric oxide (NO); (c) the ability of apoE to inhibit the proliferation of T-lymphocytes by internalization of the IL-2 receptor; and (d) the ability of apoE to inhibit proliferation of endothelial cells by out competing growth factors for interaction with cell surface heparan sulfate proteoglycans (HSPG's). The characterization of apoE and its many functions has provided insight into the ultimate potential of this protein as a possible therapeutic agent for the treatment of atherosclerosis. This review will examine key scientific advances, which focus on possible therapeutic strategies that encompass the use of apoE in the amelioration of...Continue Reading

Citations

May 22, 2003·Progress in Biophysics and Molecular Biology·Victor Martin Bolanos-Garcia, Ricardo Nunez Miguel
Jan 30, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Cai LiZhou Zheng
Nov 28, 2006·Atherosclerosis·Leila BockschAlexandra Lucas
Sep 29, 2004·Biochimica Et Biophysica Acta·In Kwan HwangSeung-Taek Lee
Nov 22, 2005·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Mohammad Warda, Robert J Linhardt
Sep 13, 2005·Biochemical Pharmacology·Tom Hsun-Wei HuangBasil D Roufogalis
Feb 26, 2010·Journal of Biomedicine & Biotechnology·Hong-liang ZhangJie Zhu
Dec 14, 2006·Phytotherapy Research : PTR·Venil N Sumantran
Sep 24, 2005·Nephron. Experimental Nephrology·Yixiang ZhangHirohito Tsubouchi
Mar 9, 2007·The Proceedings of the Nutrition Society·Eliz Anil
Jan 24, 2017·Frontiers in Pharmacology·Carlota RecioVincenzo De Feo
Dec 14, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Oleg F SharifovHimanshu Gupta
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tracey A StephensBhagirath Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.