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Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling

bioRxiv

Jan 14, 2020

Antonino AsaroThomas Willnow

Abstract

ApoE is a carrier for brain lipids and the most important genetic risk factor for Alzheimer disease (AD). ApoE binds the receptor sortilin which mediates uptake of apoE-bound cargo into neurons. The significance of this uptake route for brain lipid homeostasis and AD risk seen with apoE...read more

Mentioned in this Paper

Protein Isoforms
Uptake
Mouse Model
Neurons
Sortilin
Receptors, Nuclear
Drug Carriers
Apolipoprotein E3
Gene Expression
APOE gene
16
Paper Details
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Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling

bioRxiv

Jan 14, 2020

Antonino AsaroThomas Willnow

DOI: 10.1101/2020.01.12.903187

Abstract

ApoE is a carrier for brain lipids and the most important genetic risk factor for Alzheimer disease (AD). ApoE binds the receptor sortilin which mediates uptake of apoE-bound cargo into neurons. The significance of this uptake route for brain lipid homeostasis and AD risk seen with apoE...read more

Mentioned in this Paper

Protein Isoforms
Uptake
Mouse Model
Neurons
Sortilin
Receptors, Nuclear
Drug Carriers
Apolipoprotein E3
Gene Expression
APOE gene
16

Similar Papers Found In These Feeds

Alzheimer's Disease: Transcription

Transcription involves copying (transcribing) the gene's DNA sequence into RNA. Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and this disease.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's Disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's Disease here.

Related Papers

Journal of Biomedical Science

Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture

Journal of Biomedical ScienceJuly 13, 2013
Aseem HussainBritto P Nathan
Molecular and Cellular Biochemistry

Why lipids are important for Alzheimer disease?

Molecular and Cellular BiochemistryJanuary 1, 2009
Veronica Hirsch-ReinshagenCheryl L Wellington
Paper Details
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