Apolipoprotein E4 reduces risk of diabetic nephropathy in patients with NIDDM

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
H KimuraM Arakawa

Abstract

Hypercholesterolemia is a major determinant of the decline of renal function in patients with diabetes. Apolipoprotein E polymorphism may influence the metabolism of lipoprotein in diabetic patients. The purpose of this study was to investigate the association between genetic polymorphisms in apolipoprotein E and the progression of diabetic nephropathy in patients with non-insulin-dependent diabetes mellitus over a 10-year period (13 to 37 years; median, 20 years). Subjects with a stable renal function without overt proteinuria had a higher cholesterol level, lower incidences of hypertension and proliferative diabetic retinopathy, and a higher frequency of the E4 allele than subjects with a decline in renal function (end-stage renal failure requiring dialysis treatment). In the diabetic patients, the apolipoprotein E4 carriers had a higher cholesterol level than did the noncarriers. The survival rate from renal disease in the apolipoprotein E4 carriers was higher than in the noncarriers among the diabetic patients. Apolipoprotein E polymorphism and hypertension were identified as independent risk factors for the progression to renal failure. Results indicate that apolipoprotein E polymorphism is associated with the progression ...Continue Reading

Citations

Jun 22, 2011·Genetic Testing and Molecular Biomarkers·Min-Jie WenChang-Hsun Hsieh
Feb 25, 2011·American Journal of Nephrology·Kai-Jen TienMing-Chia Hsieh
Mar 11, 2009·PloS One·Cynthia Cooper WorobeyGary C Curhan
Sep 13, 2013·Clinical and Experimental Nephrology·Shin-ichi Araki
Nov 23, 2006·Current Diabetes Reports·Rey F Rosario, Sharma Prabhakar
Sep 9, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Shuk-Woon MaVincent T F Yeung
May 8, 2007·Diabetes Research and Clinical Practice·Elba LeivaMiguel Arredondo
Jun 27, 2006·Diabetes & Metabolism·L Morbois-TrabutP Lecomte
Jan 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Takao SaitoShinichi Oikawa
Jul 21, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Evagelos N LiberopoulosMoses S Elisaf
Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaaki EtoKohei Kaku
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Evagelos LiberopoulosMoses Elisaf
Jun 7, 2005·Diabetes Research and Clinical Practice·Elba LeivaMiguel Arredondo
Jul 28, 2004·The Annals of Thoracic Surgery·G Burkhard MacKensenUNKNOWN Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.) Investigators of the Duke Heart Center
Apr 20, 2006·Diabetes Research and Clinical Practice·Puneet Pal SinghSarabjit Mastana
Apr 12, 2005·Advances in Chronic Kidney Disease·Grzegorz PlachaAndrzej S Krolewski
Oct 30, 2014·Frontiers in Endocrinology·Sandra MerscherArmando J Mendez
Aug 23, 2005·Nephron. Experimental Nephrology·Nicola JossJ Michael Boulton-Jones
Apr 22, 2005·Scandinavian Journal of Urology and Nephrology·Louis RoussosClaes-Henrik Floren
Jun 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Evagelos N LiberopoulosMoses S Elisaf
Jan 4, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Robert B Yates, Mark Stafford-Smith
Aug 26, 2006·Cell Biochemistry and Function·Necip IlhanRamis Colak
Dec 31, 2005·Journal of the American Society of Nephrology : JASN·Eva BoesFlorian Kronenberg
Sep 6, 2005·International Urology and Nephrology·L RoussosClaes-Henrik Florén
Mar 21, 2006·Current Opinion in Anaesthesiology·Christine Rinder
Oct 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Barry I FreedmanDonald W Bowden

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Related Papers

The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
Jae-Young UmSeung-Heon Hong
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
M EtoKohei Kaku
Current Diabetes Reports
Zoltan VajoDepartment of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT)
© 2022 Meta ULC. All rights reserved