PMID: 15374124Mar 1, 1997Paper

Apolipoprotein Eepsilon4 allele, a risk factor for late onset nonfamilial Alzheimer's disease among Israeli Jews

Archives of Gerontology and Geriatrics
G FriedmanA Ben-Yehuda

Abstract

Apolipoprotein (apoE) genotypes were determined in 90 Israeli Jews with late onset sporadic Alzheimer's Disease (AD) and in 90 age- and sex-matched non-demented controls. The percentage of subjects carrying at least one apoEepsilon4 allele was 6% among the controls, and 42% among the patients (P<0.001), indicating a strong association between late onset sporadic AD and the apoEepsilon4 allele. However, no association was found between the apoEepsilon4 allele in demented and non-demented Jewish Israeli patients with Down's syndrome or Creutzfeldt-Jakob disease (CJD). The data presented in this paper confirmed several recent reports, suggesting that the apoEepsilon4 allele is a risk factor for the development of AD but not for the development of CJD or Down's syndrome among Israeli Jews.

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Citations

Dec 18, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yunfei WeiChao Qin
Mar 2, 2021·Journal of Alzheimer's Disease : JAD·Tamara ShinerNoa Bregman

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