PMID: 16634464Apr 26, 2006Paper

Apolipoprotein epsilon-4 allele and the two-year progression of cognitive function in Chinese subjects with late-onset Alzheimer's disease

American Journal of Alzheimer's Disease and Other Dementias
Linda C W LamHelen F K Chiu

Abstract

Although the significance of apolipoprotein E4 (Apo E4) in Alzheimer's disease (AD) has been well established in Caucasian populations, its role in determining the rate of cognitive decline in other ethnic groups has yet to be determined. This study examined the two-year progression of cognitive decline and its association with Apo E4 allelic status in a group of Chinese elderly subjects with AD. One hundred and four Chinese subjects with mild and moderate AD as assessed by the Clinical Dementia Rating (CDR 1 and 2) were followed up at a mean (SD) duration of 22.53 (5.21) months. The rate of cognitive decline and its association with Apo E4 allelic status was evaluated At follow-up, 74 (73 percent) subjects were reassessed. Forty-nine remained stable at the same CDR and 25 had deteriorated. The mean (SD) deterioration in the Mini-Mental State Examination (MMSE) was 2.52 (4.38) and in the Mattis Dementia Rating Scale (DRS) was 9.03 (14.98) (paired t-test, p < 0. 001). There was no significant difference in the baseline MMSE and DRS scores between the "stable", "deteriorated", or "deceased" groups. Mildly demented subjects with the Apo E4 allele were more likely to have deteriorated to a more severe CDR than subjects without the ...Continue Reading

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Citations

Feb 10, 2010·American Journal of Alzheimer's Disease and Other Dementias·Amy R Borenstein Zhen Hong
Dec 3, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Sheng-Ying YangYen-Ching Chen
Sep 22, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Deniz Erten-LyonsJeffrey Kaye
Oct 9, 2007·Current Opinion in Psychiatry·Helen Fung-Kum ChiuLinda Chiu-Wa Lam
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·David A Loeffler

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